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A look at uterine wound healing through a histopathological study of uterine scars.

Publication ,  Journal Article
Roeder, HA; Cramer, SF; Leppert, PC
Published in: Reprod Sci
May 2012

BACKGROUND: Few histopathologic studies of uterine wound healing have been published compared with similar healing in other tissues. Our objective was to examine the histopathology resulting from iatrogenic trauma to the myometrium to acquire a better understanding of possible aberrations in uterine wound healing. METHODS: We studied paired injured myometrium and uninvolved myometrium from 7 hysterectomy specimens. All subjects had either abnormal bleeding or chronic pain following an iatrogenic injury to the myometrium. The time between the initial injury and hysterectomy ranged from 2 months to 13 years. Tissue was evaluated with hematoxylin and eosin (H&E) followed by Masson Trichrome staining for collagen, Weigert-Van Gieson elastic staining, and/or Kreyberg staining for fibrin and glycosaminoglycans or MIB-1 (Ki-67) immunhistochemistry for cell proliferation. RESULTS: Histopathologic examination of the 7 paired tissues revealed evidence of altered healing including myofiber disarray, elastosis, tissue edema, and inflammation. Small fibroids, myometrial hyperplasia, a keloid-like region of scar and adenomyosis were also observed. CONCLUSIONS: Myofiber disarray and elastosis may be markers of aberrancy in wound healing after iatrogenic uterine trauma. Altered myometrial scarring in these cases may have contributed to the clinical outcome necessitating hysterectomies. Myometrial hyperplasia in the region of the scars might also contribute to the clinical presentation as well. Small fibroids found within scars and evidence of a keloid-like structure may also represent alterations in uterine wound healing.

Duke Scholars

Published In

Reprod Sci

DOI

EISSN

1933-7205

Publication Date

May 2012

Volume

19

Issue

5

Start / End Page

463 / 473

Location

United States

Related Subject Headings

  • Wound Healing
  • Uterus
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Middle Aged
  • Ki-67 Antigen
  • Immunohistochemistry
  • Iatrogenic Disease
  • Hysterectomy
  • Hyperplasia
 

Citation

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ICMJE
MLA
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Roeder, H. A., Cramer, S. F., & Leppert, P. C. (2012). A look at uterine wound healing through a histopathological study of uterine scars. Reprod Sci, 19(5), 463–473. https://doi.org/10.1177/1933719111426603
Roeder, Hilary A., Stewart F. Cramer, and Phyllis C. Leppert. “A look at uterine wound healing through a histopathological study of uterine scars.Reprod Sci 19, no. 5 (May 2012): 463–73. https://doi.org/10.1177/1933719111426603.
Roeder HA, Cramer SF, Leppert PC. A look at uterine wound healing through a histopathological study of uterine scars. Reprod Sci. 2012 May;19(5):463–73.
Roeder, Hilary A., et al. “A look at uterine wound healing through a histopathological study of uterine scars.Reprod Sci, vol. 19, no. 5, May 2012, pp. 463–73. Pubmed, doi:10.1177/1933719111426603.
Roeder HA, Cramer SF, Leppert PC. A look at uterine wound healing through a histopathological study of uterine scars. Reprod Sci. 2012 May;19(5):463–473.
Journal cover image

Published In

Reprod Sci

DOI

EISSN

1933-7205

Publication Date

May 2012

Volume

19

Issue

5

Start / End Page

463 / 473

Location

United States

Related Subject Headings

  • Wound Healing
  • Uterus
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Middle Aged
  • Ki-67 Antigen
  • Immunohistochemistry
  • Iatrogenic Disease
  • Hysterectomy
  • Hyperplasia