Skip to main content
Journal cover image

Intracerebroventricular nicotine and mecamylamine alter radial‐arm maze performance in rats

Publication ,  Journal Article
Brucato, FH; Levin, ED; Rose, JE; Swartzwelder, HS
Published in: Drug Development Research
January 1, 1994

In rats, the effects of an intracerebroventricular (ICV) nicotinic agonist nicotine (NIC), the nicotinic antagonist mecamylamine (MEC), and combinations of NIC + MEC were assessed in a radial‐arm maze (RAM). In experiment 1, exploratory behavior was assessed in untrained rats (N = 13). The rats received 4 μg, 8.65 nmol NIC (NIC 4), 200 μg, 0.98 μmol MEC (MEC), and saline (SAL) ICV infusions. NIC 4 caused a significant increase in choice distribution compared to SAL (P < 0.025). In experiment 2, rats (N = 10) were trained to perform a working memory task for food reinforcement in the RAM. ICV doses of SAL, NIC 4, NIC 8, MEC, MECNIC 4, and MECNIC 8 were administered after completion of the training period. MEC caused a significant deficit in choice accuracy when compared to SAL (P < 0.025). This deficit was reversed when NIC 8 was coadministered with MEC (P < 0.05). There were no significant effects on choice latency for either study. The effects of ICV NIC and MEC on RAM performance are generally similar to their systemic effects in that NIC improves and MEC impairs choice accuracy. The reversal of the MEC‐induced choice deficit by ICV NIC administration has not been reported with systemic administration. ICV MEC induces a choice accuracy deficit without increasing choice latency. This has not been seen with systemic MEC administration. The current result implies that the MEC‐induced choice accuracy deficit did not result from MEC‐induced sedation. The data indicate that previously reported changes in choice accuracy from peripherally administered NIC and MEC result from their central effects. © 1994 Wiley‐Liss, Inc. Copyright © 1994 Wiley‐Liss, Inc.

Duke Scholars

Published In

Drug Development Research

DOI

EISSN

1098-2299

ISSN

0272-4391

Publication Date

January 1, 1994

Volume

31

Issue

1

Start / End Page

18 / 23

Related Subject Headings

  • Pharmacology & Pharmacy
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Brucato, F. H., Levin, E. D., Rose, J. E., & Swartzwelder, H. S. (1994). Intracerebroventricular nicotine and mecamylamine alter radial‐arm maze performance in rats. Drug Development Research, 31(1), 18–23. https://doi.org/10.1002/ddr.430310104
Brucato, F. H., E. D. Levin, J. E. Rose, and H. S. Swartzwelder. “Intracerebroventricular nicotine and mecamylamine alter radial‐arm maze performance in rats.” Drug Development Research 31, no. 1 (January 1, 1994): 18–23. https://doi.org/10.1002/ddr.430310104.
Brucato FH, Levin ED, Rose JE, Swartzwelder HS. Intracerebroventricular nicotine and mecamylamine alter radial‐arm maze performance in rats. Drug Development Research. 1994 Jan 1;31(1):18–23.
Brucato, F. H., et al. “Intracerebroventricular nicotine and mecamylamine alter radial‐arm maze performance in rats.” Drug Development Research, vol. 31, no. 1, Jan. 1994, pp. 18–23. Scopus, doi:10.1002/ddr.430310104.
Brucato FH, Levin ED, Rose JE, Swartzwelder HS. Intracerebroventricular nicotine and mecamylamine alter radial‐arm maze performance in rats. Drug Development Research. 1994 Jan 1;31(1):18–23.
Journal cover image

Published In

Drug Development Research

DOI

EISSN

1098-2299

ISSN

0272-4391

Publication Date

January 1, 1994

Volume

31

Issue

1

Start / End Page

18 / 23

Related Subject Headings

  • Pharmacology & Pharmacy
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences