Symmetry breaking and the establishment of cell polarity in budding yeast.

Journal Article (Journal Article;Review)

Cell polarity is typically oriented by external cues such as cell-cell contacts, chemoattractants, or morphogen gradients. In the absence of such cues, however, many cells can spontaneously polarize in a random direction, suggesting the existence of an internal polarity-generating mechanism whose direction can be spatially biased by external cues. Spontaneous 'symmetry-breaking' polarization is likely to involve an autocatalytic process set off by small random fluctuations. Here we review recent work on the nature of the autocatalytic process in budding yeast and on the question of why polarized cells only develop a single 'front'.

Full Text

Duke Authors

Cited Authors

  • Johnson, JM; Jin, M; Lew, DJ

Published Date

  • December 2011

Published In

Volume / Issue

  • 21 / 6

Start / End Page

  • 740 - 746

PubMed ID

  • 21955794

Pubmed Central ID

  • PMC3224179

Electronic International Standard Serial Number (EISSN)

  • 1879-0380

Digital Object Identifier (DOI)

  • 10.1016/j.gde.2011.09.007


  • eng

Conference Location

  • England