Different G1 cyclins control the timing of cell cycle commitment in mother and daughter cells of the budding yeast S. cerevisiae.

Published

Journal Article

Growth of S. cerevisiae cells by budding gives rise to asymmetric progeny cells: a larger "mother" cell and a smaller "daughter" cell. The mother cell transits a brief G1 phase before forming a new bud and beginning DNA replication. The daughter cell stays in G1 for a longer period, growing in size before initiating a new cell cycle. We show that the timing of cell cycle initiation in mother and daughter cells is governed by different G1 cyclins. In daughter cells, transcription of CLN1 and CLN2 is induced in a size-dependent manner, and these cyclins are necessary for the normal timing of cell cycle initiation. CLN3 is not required in daughter cells, but is crucial for mother cells, in which the G1 phase is much longer in the absence of this cyclin.

Full Text

Duke Authors

Cited Authors

  • Lew, DJ; Marini, NJ; Reed, SI

Published Date

  • April 17, 1992

Published In

Volume / Issue

  • 69 / 2

Start / End Page

  • 317 - 327

PubMed ID

  • 1533176

Pubmed Central ID

  • 1533176

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(92)90412-6

Language

  • eng

Conference Location

  • United States