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Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study.

Publication ,  Journal Article
Nordli, DR; Moshé, SL; Shinnar, S; Hesdorffer, DC; Sogawa, Y; Pellock, JM; Lewis, DV; Frank, LM; Shinnar, RC; Sun, S; FEBSTAT Study Team,
Published in: Neurology
November 27, 2012

OBJECTIVE: The FEBSTAT (Consequences of Prolonged Febrile Seizures) study is prospectively addressing the relationships among serial EEG, MRI, and clinical follow-up in a cohort of children followed from the time of presentation with febrile status epilepticus (FSE). METHODS: We recruited 199 children with FSE within 72 hours of presentation. Children underwent a detailed history, physical examination, MRI, and EEG within 72 hours. All EEGs were read by 2 teams and then conferenced. Associations with abnormal EEG were determined using logistic regression. Interrater reliability was assessed using the κ statistic. RESULTS: Of the 199 EEGs, 90 (45.2%) were abnormal with the most common abnormality being focal slowing (n = 47) or attenuation (n = 25); these were maximal over the temporal areas in almost all cases. Epileptiform abnormalities were present in 13 EEGs (6.5%). In adjusted analysis, the odds of focal slowing were significantly increased by focal FSE (odds ratio [OR] = 5.08) and hippocampal T2 signal abnormality (OR = 3.50) and significantly decreased with high peak temperature (OR = 0.18). Focal EEG attenuation was also associated with hippocampal T2 signal abnormality (OR = 3.3). CONCLUSIONS: Focal EEG slowing or attenuation are present in EEGs obtained within 72 hours of FSE in a substantial proportion of children and are highly associated with MRI evidence of acute hippocampal injury. These findings may be a sensitive and readily obtainable marker of acute injury associated with FSE.

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Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

November 27, 2012

Volume

79

Issue

22

Start / End Page

2180 / 2186

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Seizures, Febrile
  • Neurology & Neurosurgery
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Female
  • Electroencephalography
  • Child, Preschool
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nordli, D. R., Moshé, S. L., Shinnar, S., Hesdorffer, D. C., Sogawa, Y., Pellock, J. M., … FEBSTAT Study Team, . (2012). Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study. Neurology, 79(22), 2180–2186. https://doi.org/10.1212/WNL.0b013e3182759766
Nordli, Douglas R., Solomon L. Moshé, Shlomo Shinnar, Dale C. Hesdorffer, Yoshimi Sogawa, John M. Pellock, Darrell V. Lewis, et al. “Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study.Neurology 79, no. 22 (November 27, 2012): 2180–86. https://doi.org/10.1212/WNL.0b013e3182759766.
Nordli DR, Moshé SL, Shinnar S, Hesdorffer DC, Sogawa Y, Pellock JM, et al. Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study. Neurology. 2012 Nov 27;79(22):2180–6.
Nordli, Douglas R., et al. “Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study.Neurology, vol. 79, no. 22, Nov. 2012, pp. 2180–86. Pubmed, doi:10.1212/WNL.0b013e3182759766.
Nordli DR, Moshé SL, Shinnar S, Hesdorffer DC, Sogawa Y, Pellock JM, Lewis DV, Frank LM, Shinnar RC, Sun S, FEBSTAT Study Team. Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study. Neurology. 2012 Nov 27;79(22):2180–2186.

Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

November 27, 2012

Volume

79

Issue

22

Start / End Page

2180 / 2186

Location

United States

Related Subject Headings

  • Status Epilepticus
  • Seizures, Febrile
  • Neurology & Neurosurgery
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Female
  • Electroencephalography
  • Child, Preschool