Imaging molecular pathways: reporter genes.

Journal Article (Journal Article;Review)

Molecular imaging is a rapidly advancing field that allows cancer biologists to look deeper into the complex inner workings of tumor cells, or whole tumors, in a non-invasive manner. In this review, we will summarize some recent advances that enable investigators to study various important biological processes in tumors in vivo. We will discuss novel imaging approaches that allow investigators to visualize and quantify molecular pathways, such as receptor tyrosine kinase activation, hypoxia signal transduction, apoptosis, and DNA double-strand breaks. Select examples of these applications will be discussed. Because of the limited scope of this review, we will only focus on natural reporters, such as bioluminescence and fluorescent proteins.

Full Text

Duke Authors

Cited Authors

  • Brogan, J; Li, F; Li, W; He, Z; Huang, Q; Li, C-Y

Published Date

  • April 2012

Published In

Volume / Issue

  • 177 / 4

Start / End Page

  • 508 - 513

PubMed ID

  • 22348248

Pubmed Central ID

  • PMC3595018

Electronic International Standard Serial Number (EISSN)

  • 1938-5404

Digital Object Identifier (DOI)

  • 10.1667/rr2918.1


  • eng

Conference Location

  • United States