Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.

Published

Journal Article

The ability to regenerate damaged tissues is a common characteristic of multicellular organisms. We report a role for apoptotic cell death in promoting wound healing and tissue regeneration in mice. Apoptotic cells released growth signals that stimulated the proliferation of progenitor or stem cells. Key players in this process were caspases 3 and 7, proteases activated during the execution phase of apoptosis that contribute to cell death. Mice lacking either of these caspases were deficient in skin wound healing and in liver regeneration. Prostaglandin E(2), a promoter of stem or progenitor cell proliferation and tissue regeneration, acted downstream of the caspases. We propose to call the pathway by which executioner caspases in apoptotic cells promote wound healing and tissue regeneration in multicellular organisms the "phoenix rising" pathway.

Full Text

Duke Authors

Cited Authors

  • Li, F; Huang, Q; Chen, J; Peng, Y; Roop, DR; Bedford, JS; Li, C-Y

Published Date

  • February 23, 2010

Published In

Volume / Issue

  • 3 / 110

Start / End Page

  • ra13 -

PubMed ID

  • 20179271

Pubmed Central ID

  • 20179271

Electronic International Standard Serial Number (EISSN)

  • 1937-9145

International Standard Serial Number (ISSN)

  • 1945-0877

Digital Object Identifier (DOI)

  • 10.1126/scisignal.2000634

Language

  • eng