Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.
Journal Article (Journal Article)
The ability to regenerate damaged tissues is a common characteristic of multicellular organisms. We report a role for apoptotic cell death in promoting wound healing and tissue regeneration in mice. Apoptotic cells released growth signals that stimulated the proliferation of progenitor or stem cells. Key players in this process were caspases 3 and 7, proteases activated during the execution phase of apoptosis that contribute to cell death. Mice lacking either of these caspases were deficient in skin wound healing and in liver regeneration. Prostaglandin E(2), a promoter of stem or progenitor cell proliferation and tissue regeneration, acted downstream of the caspases. We propose to call the pathway by which executioner caspases in apoptotic cells promote wound healing and tissue regeneration in multicellular organisms the "phoenix rising" pathway.
Full Text
Duke Authors
Cited Authors
- Li, F; Huang, Q; Chen, J; Peng, Y; Roop, DR; Bedford, JS; Li, C-Y
Published Date
- February 23, 2010
Published In
Volume / Issue
- 3 / 110
Start / End Page
- ra13 -
PubMed ID
- 20179271
Pubmed Central ID
- PMC2905599
Electronic International Standard Serial Number (EISSN)
- 1937-9145
Digital Object Identifier (DOI)
- 10.1126/scisignal.2000634
Language
- eng
Conference Location
- United States