Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation.

Journal Article (Journal Article)

Previously it was shown that horizontal DNA transfer between mammalian cells can occur through the uptake of apoptotic bodies, where genes from the apoptotic cells were transferred to neighbouring cells phagocytosing the apoptotic bodies. The regulation of this process is poorly understood. It was shown that the ability of cells as recipient of horizontally transferred DNA was enhanced by deficiency of p53 or p21. However, little is known with regard to the regulation of DNA from donor apoptotic cells. Here we report that the DNA fragmentation factor/caspase-activated DNase (DFF/CAD), which is the endonuclease responsible for DNA fragmentation during apoptosis, plays a significant role in regulation of horizontal DNA transfer. Cells with inhibited DFF/CAD function are poor donors for horizontal gene transfer (HGT) while their ability of being recipients of HGT is not affected.

Full Text

Duke Authors

Cited Authors

  • Yan, B; Wang, H; Li, F; Li, C-Y

Published Date

  • December 18, 2006

Published In

Volume / Issue

  • 95 / 12

Start / End Page

  • 1696 - 1700

PubMed ID

  • 17146478

Pubmed Central ID

  • PMC2360754

International Standard Serial Number (ISSN)

  • 0007-0920

Digital Object Identifier (DOI)

  • 10.1038/sj.bjc.6603484


  • eng

Conference Location

  • England