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Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation.

Publication ,  Journal Article
Yan, B; Wang, H; Li, F; Li, C-Y
Published in: Br J Cancer
December 18, 2006

Previously it was shown that horizontal DNA transfer between mammalian cells can occur through the uptake of apoptotic bodies, where genes from the apoptotic cells were transferred to neighbouring cells phagocytosing the apoptotic bodies. The regulation of this process is poorly understood. It was shown that the ability of cells as recipient of horizontally transferred DNA was enhanced by deficiency of p53 or p21. However, little is known with regard to the regulation of DNA from donor apoptotic cells. Here we report that the DNA fragmentation factor/caspase-activated DNase (DFF/CAD), which is the endonuclease responsible for DNA fragmentation during apoptosis, plays a significant role in regulation of horizontal DNA transfer. Cells with inhibited DFF/CAD function are poor donors for horizontal gene transfer (HGT) while their ability of being recipients of HGT is not affected.

Duke Scholars

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Published In

Br J Cancer

DOI

ISSN

0007-0920

Publication Date

December 18, 2006

Volume

95

Issue

12

Start / End Page

1696 / 1700

Location

England

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Phagocytosis
  • Oncology & Carcinogenesis
  • Mice, Knockout
  • Mice
  • Gene Transfer, Horizontal
  • Fibroblasts
  • Deoxyribonucleases
  • DNA Fragmentation
  • Cells, Cultured
 

Citation

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Yan, B., Wang, H., Li, F., & Li, C.-Y. (2006). Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation. Br J Cancer, 95(12), 1696–1700. https://doi.org/10.1038/sj.bjc.6603484
Yan, B., H. Wang, F. Li, and C. -. Y. Li. “Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation.Br J Cancer 95, no. 12 (December 18, 2006): 1696–1700. https://doi.org/10.1038/sj.bjc.6603484.
Yan B, Wang H, Li F, Li C-Y. Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation. Br J Cancer. 2006 Dec 18;95(12):1696–700.
Yan, B., et al. “Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation.Br J Cancer, vol. 95, no. 12, Dec. 2006, pp. 1696–700. Pubmed, doi:10.1038/sj.bjc.6603484.
Yan B, Wang H, Li F, Li C-Y. Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation. Br J Cancer. 2006 Dec 18;95(12):1696–1700.

Published In

Br J Cancer

DOI

ISSN

0007-0920

Publication Date

December 18, 2006

Volume

95

Issue

12

Start / End Page

1696 / 1700

Location

England

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Phagocytosis
  • Oncology & Carcinogenesis
  • Mice, Knockout
  • Mice
  • Gene Transfer, Horizontal
  • Fibroblasts
  • Deoxyribonucleases
  • DNA Fragmentation
  • Cells, Cultured