GW112, a novel antiapoptotic protein that promotes tumor growth.

Journal Article (Journal Article)

GW112 is a novel gene that has little homology to other known genes. It is overexpressed in a number of human tumor types, especially in those of the digestive system. We show here that GW112 is associated with GRIM-19, a protein known to be involved in regulating cellular apoptosis. Functionally, GW112 could significantly attenuate the ability of GRIM19 to mediate retinoic acid-IFN-beta-mediated cellular apoptosis and apoptosis-related gene expression. In addition, GW112 demonstrated strong antiapoptotic effects in tumor cells treated with other stress exposures such as hydrogen peroxide. Finally, forced overexpression of GW112 in murine prostate tumor cells led to more rapid tumor formation in a syngeneic host. Taken together, our data suggest that GW112 is an important regulator of cell death that plays important roles in tumor cell survival and tumor growth.

Full Text

Duke Authors

Cited Authors

  • Zhang, X; Huang, Q; Yang, Z; Li, Y; Li, C-Y

Published Date

  • April 1, 2004

Published In

Volume / Issue

  • 64 / 7

Start / End Page

  • 2474 - 2481

PubMed ID

  • 15059901

International Standard Serial Number (ISSN)

  • 0008-5472

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.can-03-3443


  • eng

Conference Location

  • United States