Distinct CD4+ helper T cells involved in primary and secondary responses to infection.

Journal Article (Journal Article)

Helper T cells are critical for protective immunity, CD8(+) T-cell memory, and CD4(+) recall responses, but whether the same or distinct CD4(+) T cells are involved in these responses has not been established. Here we describe two CD4(+) T cells, LLO118 and LLO56, specific for an immunodominant Listeria monocytogenes epitope, with dramatically different responses to primary and secondary infection. Comparing in vivo responses, LLO118 T cells proliferate more strongly to primary infection, whereas surprisingly, LLO56 has a superior CD4(+) recall response to secondary infection. LLO118 T cells provide more robust help for CD8(+) T-cell responses to secondary infection than LLO56. We found no detectable differences in antigen sensitivity, but naive LLO118 T cells have much lower levels of CD5 and their T-cell receptor levels are dramatically down-regulated after their strong primary response. Thus, distinct CD4(+) helper T cells are specialized to help either in primary or secondary responses to infection.

Full Text

Duke Authors

Cited Authors

  • Weber, KS; Li, Q-J; Persaud, SP; Campbell, JD; Davis, MM; Allen, PM

Published Date

  • June 12, 2012

Published In

Volume / Issue

  • 109 / 24

Start / End Page

  • 9511 - 9516

PubMed ID

  • 22645349

Pubmed Central ID

  • PMC3386110

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

Digital Object Identifier (DOI)

  • 10.1073/pnas.1202408109


  • eng

Conference Location

  • United States