microRNAs at the regulatory frontier: an investigation into how microRNAs impact the development and effector functions of CD4 T cells.

Published

Journal Article

CD4 T cells are an integral part of adaptive immunity. microRNAs have been identified as fundamental regulators of post-transcriptional programs and to play roles in T lymphocytes' development, differentiation, and effector functions. To better understand the role of miRNAs in T cells and to identify potential therapeutic tools and targets, we have undertaken studies of miRNAs that modulate or are modulated by T-cell receptor signaling. We identified miR-181a as a key regulator of TCR signaling strength, and hence T-cell development, and the miR-17-92 cluster as an important player in CD4 T cells' response against antigens. These discoveries, coupled with work by other researchers, reveal the power and importance of miRNA-mediated regulation in T-cell responses and offer new insights into the burgeoning field of immunoregulation.

Full Text

Duke Authors

Cited Authors

  • Lykken, EA; Li, Q-J

Published Date

  • April 2011

Published In

Volume / Issue

  • 49 / 1-3

Start / End Page

  • 87 - 96

PubMed ID

  • 21191665

Pubmed Central ID

  • 21191665

Electronic International Standard Serial Number (EISSN)

  • 1559-0755

International Standard Serial Number (ISSN)

  • 0257-277X

Digital Object Identifier (DOI)

  • 10.1007/s12026-010-8196-4

Language

  • eng