microRNAs at the regulatory frontier: an investigation into how microRNAs impact the development and effector functions of CD4 T cells.
CD4 T cells are an integral part of adaptive immunity. microRNAs have been identified as fundamental regulators of post-transcriptional programs and to play roles in T lymphocytes' development, differentiation, and effector functions. To better understand the role of miRNAs in T cells and to identify potential therapeutic tools and targets, we have undertaken studies of miRNAs that modulate or are modulated by T-cell receptor signaling. We identified miR-181a as a key regulator of TCR signaling strength, and hence T-cell development, and the miR-17-92 cluster as an important player in CD4 T cells' response against antigens. These discoveries, coupled with work by other researchers, reveal the power and importance of miRNA-mediated regulation in T-cell responses and offer new insights into the burgeoning field of immunoregulation.
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Related Subject Headings
- Signal Transduction
- Receptors, Antigen, T-Cell
- MicroRNAs
- Immunology
- Humans
- CD8-Positive T-Lymphocytes
- CD4-Positive T-Lymphocytes
- Adaptive Immunity
- 3204 Immunology
- 1107 Immunology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Signal Transduction
- Receptors, Antigen, T-Cell
- MicroRNAs
- Immunology
- Humans
- CD8-Positive T-Lymphocytes
- CD4-Positive T-Lymphocytes
- Adaptive Immunity
- 3204 Immunology
- 1107 Immunology