A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence

Journal Article

A population association between a regulatory variation in the promoter of the serotonin transporter gene (HTT) and severe alcohol dependence was recently reported. We analyzed this potential association in a large number of systematically ascertained families in the United States; these families had at least three first-degree relatives who were alcohol-dependent. Analyses focused on individuals defined as alcohol-dependent by criteria from ICD-10 and on subsets of these individuals reporting withdrawal-related symptoms. Application of the transmission disequilibrium test did not provide support for either linkage or association between this functional polymorphism and alcohol dependence; there was no significant bias in the transmission of either allele to the alcohol-dependent offspring. We also report that African Americans differ from Caucasians in allele frequencies for this polymorphism.

Cited Authors

  • Edenberg, HJ; Reynolds, J; Koller, DL; Begleiter, H; Bucholz, KK; Conneally, PM; Crowe, R; Goate, A; Hesselbrock, V; Li, TK; Jr, JIN; Porjesz, B; Reich, T; Rice, JP; Schuckit, M; Tischfield, JA; Foroud, T

Published Date

  • January 1, 1998

Published In

Volume / Issue

  • 22 / 5

Start / End Page

  • 1080 - 1085

International Standard Serial Number (ISSN)

  • 0145-6008