Skip to main content

Neurohormonal regulation of pancreatic secretion.

Publication ,  Journal Article
Chandra, R; Liddle, RA
Published in: Curr Opin Gastroenterol
September 2012

PURPOSE OF REVIEW: Recent advances in the regulation of pancreatic secretion by neural and hormonal mechanisms are discussed in this review. RECENT FINDINGS: It has been shown that the multidrug-resistance protein MRP4 may play a role in the efflux of cAMP from exocrine cells and neurokinin receptors are important in substance P-mediated inhibition of ductal bicarbonate secretion. Leptin attenuates glucagon secretion by downregulating glucagon gene expression, whereas ghrelin upregulates glucagon release by elevating intracellular calcium and phosphorylation of extracellular signal-regulated kinase (ERK). Cytokine interleukin 6 is secreted from muscles during exercise and induces the release of GLP-1 that stimulates insulin secretion. Osteocalcin and 17β-estradiol mediate their effects through G protein-coupled receptors, resulting in ERK phosphorylation and activation of protein kinase-dependent signaling pathways. Melatonin and ghrelin inhibit insulin secretion through inhibitory G proteins, whereas aldosterone may attenuate insulin secretion by increasing oxidative stress in islets cells. Finally, the pattern of innervation of human pancreatic islets has been examined and demonstrated to be very different from that in the mouse. SUMMARY: Many different receptors and signaling pathways govern the complex biology of pancreatic secretion. Elucidation of these cellular mechanisms will aid in drug discovery and treatment as well as prevention of pancreatic diseases.

Duke Scholars

Published In

Curr Opin Gastroenterol

DOI

EISSN

1531-7056

Publication Date

September 2012

Volume

28

Issue

5

Start / End Page

483 / 487

Location

United States

Related Subject Headings

  • Pancreas
  • MAP Kinase Signaling System
  • Islets of Langerhans
  • Insulin Secretion
  • Insulin
  • Humans
  • Glucagon
  • Gastroenterology & Hepatology
  • Cyclic AMP
  • Bicarbonates
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chandra, R., & Liddle, R. A. (2012). Neurohormonal regulation of pancreatic secretion. Curr Opin Gastroenterol, 28(5), 483–487. https://doi.org/10.1097/MOG.0b013e3283567f16
Chandra, Rashmi, and Rodger A. Liddle. “Neurohormonal regulation of pancreatic secretion.Curr Opin Gastroenterol 28, no. 5 (September 2012): 483–87. https://doi.org/10.1097/MOG.0b013e3283567f16.
Chandra R, Liddle RA. Neurohormonal regulation of pancreatic secretion. Curr Opin Gastroenterol. 2012 Sep;28(5):483–7.
Chandra, Rashmi, and Rodger A. Liddle. “Neurohormonal regulation of pancreatic secretion.Curr Opin Gastroenterol, vol. 28, no. 5, Sept. 2012, pp. 483–87. Pubmed, doi:10.1097/MOG.0b013e3283567f16.
Chandra R, Liddle RA. Neurohormonal regulation of pancreatic secretion. Curr Opin Gastroenterol. 2012 Sep;28(5):483–487.

Published In

Curr Opin Gastroenterol

DOI

EISSN

1531-7056

Publication Date

September 2012

Volume

28

Issue

5

Start / End Page

483 / 487

Location

United States

Related Subject Headings

  • Pancreas
  • MAP Kinase Signaling System
  • Islets of Langerhans
  • Insulin Secretion
  • Insulin
  • Humans
  • Glucagon
  • Gastroenterology & Hepatology
  • Cyclic AMP
  • Bicarbonates