Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals.

Published

Journal Article (Review)

In signal transduction of metazoan cells, ion channels of the family of transient receptor potential (TRP) have been identified to respond to diverse external and internal stimuli, amongst them osmotic stimuli. This report highlights findings pertaining to the TRPV subfamily, focusing on mammalian members. Of the six mammalian TRPV channels, TRPV1, 2 and 4 were demonstrated to function in transduction of osmotic stimuli. TRPV channels have been found to function in cellular as well as systemic osmotic homeostasis. In a striking example of evolutionary conservation of function, mammalian TRPV4 has been found to rescue osmosensory deficits of the TRPV mutant strain osm-9 in Caenorhabditis elegans, despite not more than 26% orthology of the respective proteins.

Full Text

Duke Authors

Cited Authors

  • Liedtke, W

Published Date

  • May 2007

Published In

Volume / Issue

  • 92 / 3

Start / End Page

  • 507 - 512

PubMed ID

  • 17350992

Pubmed Central ID

  • 17350992

International Standard Serial Number (ISSN)

  • 0958-0670

Digital Object Identifier (DOI)

  • 10.1113/expphysiol.2006.035642

Language

  • eng

Conference Location

  • England