Capsaicin binds and acts at the vanilloid receptor, and causes initial excitatory actions. After long-term application, desensitisation of pain afferents is observed. Therapeutic trials and clinical studies have been performed with different forms of neuralgias. The analgetic effect has been substantiated for post-herpetic neuralgia and painful diabetic neuralgia. Other indications, such as neurogenic bladder disturbance, cluster headache, and pruritus are still in the experimental stage.
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