Mapping of the mouse Rar loci encoding retinoic acid receptors RAR alpha, RAR beta and RAR gamma.

Published

Journal Article

Nuclear retinoic acid receptors RAR alpha, RAR beta and RAR gamma are transcription factors that bind all-trans retinoic acid as their ligand and mediate its action by activating particular set of genes that contain retinoic acid responsive elements in their promoter-enhancers. We have mapped genetic loci for these genes using restriction fragment length variants (RFLVs) in interspecific backcross mice. None of the Rar loci cosegregated with each other or with the new subclass of retinoid receptors, Rxr loci. Rara mapped to mChr 11, Rarb mapped to mChr 14, and Rarg mapped to mChr 15. The results are consistent with the previous reports and the human data in terms of syntenic homology between mouse and human chromosomes.

Full Text

Duke Authors

Cited Authors

  • Taketo, M; Hoopes, C; Howard, TA; Linney, E; Seldin, MF

Published Date

  • June 1, 1993

Published In

Volume / Issue

  • 68 / 3

Start / End Page

  • 175 - 184

PubMed ID

  • 8251184

Pubmed Central ID

  • 8251184

International Standard Serial Number (ISSN)

  • 0021-504X

Digital Object Identifier (DOI)

  • 10.1266/jjg.68.175

Language

  • eng

Conference Location

  • Japan