Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma.
Publication
, Journal Article
Hoopes, CW; Taketo, M; Ozato, K; Liu, Q; Howard, TA; Linney, E; Seldin, MF
Published in: Genomics
November 1992
Recently, a novel subgroup of nuclear hormone receptors called RXRs implicated for retinoid-mediated gene regulation have been identified. RXRs appear to interact with many other nuclear hormone receptors and modulate their functions. We have mapped genetic loci Rxra, Rxrb, and Rxrg encoding three RXR subtypes, RXR alpha, RXR beta, and RXR gamma, respectively, using interspecific backcross mice. None of the Rxr loci cosegregated with each other or with the retinoic acid receptor loci (Rar) mapped previously. Rxra mapped to Chr 2 near the centromere, Rxrb mapped to the H-2 region of Chr 17, and Rxrg was tightly linked to the Pbx gene on distal Chr 1. These results underscore that RXR genes are dispersed in the genome.
Duke Scholars
Published In
Genomics
DOI
ISSN
0888-7543
Publication Date
November 1992
Volume
14
Issue
3
Start / End Page
611 / 617
Location
United States
Related Subject Headings
- Transcription Factors
- Retinoid X Receptors
- Receptors, Retinoic Acid
- Receptors, Cell Surface
- Polymorphism, Restriction Fragment Length
- Nuclear Proteins
- Muridae
- Molecular Sequence Data
- Mice, Inbred C3H
- Mice, Inbred BALB C
Citation
APA
Chicago
ICMJE
MLA
NLM
Hoopes, C. W., Taketo, M., Ozato, K., Liu, Q., Howard, T. A., Linney, E., & Seldin, M. F. (1992). Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma. Genomics, 14(3), 611–617. https://doi.org/10.1016/s0888-7543(05)80159-4
Hoopes, C. W., M. Taketo, K. Ozato, Q. Liu, T. A. Howard, E. Linney, and M. F. Seldin. “Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma.” Genomics 14, no. 3 (November 1992): 611–17. https://doi.org/10.1016/s0888-7543(05)80159-4.
Hoopes CW, Taketo M, Ozato K, Liu Q, Howard TA, Linney E, et al. Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma. Genomics. 1992 Nov;14(3):611–7.
Hoopes, C. W., et al. “Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma.” Genomics, vol. 14, no. 3, Nov. 1992, pp. 611–17. Pubmed, doi:10.1016/s0888-7543(05)80159-4.
Hoopes CW, Taketo M, Ozato K, Liu Q, Howard TA, Linney E, Seldin MF. Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXR alpha, RXR beta, and RXR gamma. Genomics. 1992 Nov;14(3):611–617.
Published In
Genomics
DOI
ISSN
0888-7543
Publication Date
November 1992
Volume
14
Issue
3
Start / End Page
611 / 617
Location
United States
Related Subject Headings
- Transcription Factors
- Retinoid X Receptors
- Receptors, Retinoic Acid
- Receptors, Cell Surface
- Polymorphism, Restriction Fragment Length
- Nuclear Proteins
- Muridae
- Molecular Sequence Data
- Mice, Inbred C3H
- Mice, Inbred BALB C