Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells.
Publication
, Journal Article
Linney, E; Davis, B; Overhauser, J; Chao, E; Fan, H
Published in: Nature
March 29, 1984
Moloney murine leukaemia virus (M-MuLV) infection of embryonal carcinoma (EC) cells results in the integration of proviral DNA into the host cell genome, but not in virus production. One suggested explanation for the lack of viral gene expression in EC cells has been methylation of the integrated viral DNA. However, subsequent reports indicated that integration of the M-MuLV DNA occurs soon after infection, but that viral DNA methylation occurs considerably later. Nevertheless, viral gene expression is not observed even at early times. One possible explanation is that certain M-MuLV regulatory sequences do not function in EC cells. We now present evidence which supports this hypothesis.
Duke Scholars
Published In
Nature
DOI
ISSN
0028-0836
Publication Date
March 29, 1984
Volume
308
Issue
5958
Start / End Page
470 / 472
Location
England
Related Subject Headings
- Transfection
- Teratoma
- Stem Cells
- Plasmids
- Neoplastic Stem Cells
- Moloney murine leukemia virus
- Mice
- Genes, Viral
- Genes, Regulator
- General Science & Technology
Citation
APA
Chicago
ICMJE
MLA
NLM
Linney, E., Davis, B., Overhauser, J., Chao, E., & Fan, H. (1984). Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells. Nature, 308(5958), 470–472. https://doi.org/10.1038/308470a0
Linney, E., B. Davis, J. Overhauser, E. Chao, and H. Fan. “Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells.” Nature 308, no. 5958 (March 29, 1984): 470–72. https://doi.org/10.1038/308470a0.
Linney E, Davis B, Overhauser J, Chao E, Fan H. Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells. Nature. 1984 Mar 29;308(5958):470–2.
Linney, E., et al. “Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells.” Nature, vol. 308, no. 5958, Mar. 1984, pp. 470–72. Pubmed, doi:10.1038/308470a0.
Linney E, Davis B, Overhauser J, Chao E, Fan H. Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells. Nature. 1984 Mar 29;308(5958):470–472.
Published In
Nature
DOI
ISSN
0028-0836
Publication Date
March 29, 1984
Volume
308
Issue
5958
Start / End Page
470 / 472
Location
England
Related Subject Headings
- Transfection
- Teratoma
- Stem Cells
- Plasmids
- Neoplastic Stem Cells
- Moloney murine leukemia virus
- Mice
- Genes, Viral
- Genes, Regulator
- General Science & Technology