Stimulation strength and focality of electroconvulsive therapy with individualized current amplitude: a preclinical study.

Published

Journal Article

This study investigates the stimulation strength and focality of electroconvulsive therapy (ECT) with individualized current amplitude in a nonhuman primate (NHP) model. We generated an anatomically realistic finite element model of a NHP head incorporating tissue heterogeneity and white matter conductivity anisotropy based on structural magnetic resonance imaging (MRI) and diffusion tensor MRI data. The electric field spatial distributions of three conventional ECT electrode placements (bilateral, bifrontal, and right unilateral) and an experimental frontomedial electrode configuration were simulated. We calibrated the electric field maps relative to an empirical neural activation threshold and evaluated the stimulation strength and focality of the various ECT electrode configurations with individualized current amplitudes corresponding to the motor threshold and seizure threshold assessed in the anesthetized NHP. Understanding the stimulation strength and focality of various forms of ECT could provide insight into the mechanisms of therapeutic seizure induction, and could provide support for the clinical investigation of ECT with individualized current amplitude as an intervention with potentially improved risk/benefit ratio.

Full Text

Duke Authors

Cited Authors

  • Lee, WH; Lisanby, SH; Laine, AF; Peterchev, AV

Published Date

  • 2012

Published In

Volume / Issue

  • 2012 /

Start / End Page

  • 6430 - 6433

PubMed ID

  • 23367401

Pubmed Central ID

  • 23367401

International Standard Serial Number (ISSN)

  • 1557-170X

Digital Object Identifier (DOI)

  • 10.1109/EMBC.2012.6347466

Language

  • eng

Conference Location

  • United States