Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS).

Published

Journal Article

There is evidence that motor and premotor cortex are hyperexcitable in obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS). We tested whether low-frequency repetitive transcranial magnetic stimulation (rTMS) could normalize overactive motor cortical regions and thereby improve symptoms. Subjects with OCD or TS were treated with active rTMS to the supplementary motor area (SMA) for 10 daily sessions at 1 Hz, 100% of motor threshold, 1200 stimuli/day. Suggestions of clinical improvement were apparent as early as the first week of rTMS. At the second week of treatment, statistically significant reductions were seen in the YBOCS, YGTSS, CGI, HARS, HDRS, SAD, BDI, SCL-90, and SASS. Symptoms improvement was correlated with a significant increase of the right resting motor threshold and was stable at 3 months follow-up. Slow rTMS to SMA resulted in a significant clinical improvement and a normalization of the right hemisphere hyperexcitability, thereby restoring hemispheric symmetry in motor threshold.

Full Text

Duke Authors

Cited Authors

  • Mantovani, A; Lisanby, SH; Pieraccini, F; Ulivelli, M; Castrogiovanni, P; Rossi, S

Published Date

  • February 2006

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 95 - 100

PubMed ID

  • 15982444

Pubmed Central ID

  • 15982444

International Standard Serial Number (ISSN)

  • 1461-1457

Digital Object Identifier (DOI)

  • 10.1017/S1461145705005729

Language

  • eng

Conference Location

  • England