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Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings.

Publication ,  Journal Article
Boutros, NN; Lisanby, SH; McClain-Furmanski, D; Oliwa, G; Gooding, D; Kosten, TR
Published in: J Psychiatr Res
May 2005

Cortical excitability can be assessed by transcranial magnetic stimulation (TMS). Previously we observed that TMS motor threshold (MT) was elevated in abstinent cocaine-dependent subjects. In the current study we aimed at replicating our initial finding, exploring other TMS-based measures of excitability, and examining association with personality characteristics. Nineteen cocaine-dependent and 12 healthy control subjects were examined. Resting and activated motor thresholds (RMT and AMT) and duration of the cortical silent period (CSP) were examined. The Cocaine Experience Questionnaire (CEQ) was administered to assess cocaine-induced psychotic symptoms. The relationship between Minnesota Multiphasic Personality Inventory (MMPI) scales and cortical excitability measures was also examined. AMT was significantly elevated in cocaine-dependent subjects on both hemispheres. RMT was also significantly elevated on the right hemisphere. No CSP changes were noted. Patients with cocaine-induced paranoia had longer CSPs on the right hemisphere compared to subjects reporting no paranoid experiences. The patients displayed significantly elevated scores on several MMPI scales, though the scale scores did not correlate with cortical excitability measures. These data support our initial finding of decreased cortical excitability in abstinent cocaine-dependent subjects. We interpret this finding as a compensatory mechanism against the stimulating and epileptogenic effects of cocaine.

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Published In

J Psychiatr Res

DOI

ISSN

0022-3956

Publication Date

May 2005

Volume

39

Issue

3

Start / End Page

295 / 302

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Skull
  • Psychiatry
  • Personality Disorders
  • Motor Cortex
  • Middle Aged
  • Male
  • Magnetics
  • MMPI
  • Humans
 

Citation

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Boutros, N. N., Lisanby, S. H., McClain-Furmanski, D., Oliwa, G., Gooding, D., & Kosten, T. R. (2005). Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings. J Psychiatr Res, 39(3), 295–302. https://doi.org/10.1016/j.jpsychires.2004.07.002
Boutros, Nashaat N., Sarah H. Lisanby, Dennis McClain-Furmanski, Glen Oliwa, Diane Gooding, and Thomas R. Kosten. “Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings.J Psychiatr Res 39, no. 3 (May 2005): 295–302. https://doi.org/10.1016/j.jpsychires.2004.07.002.
Boutros NN, Lisanby SH, McClain-Furmanski D, Oliwa G, Gooding D, Kosten TR. Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings. J Psychiatr Res. 2005 May;39(3):295–302.
Boutros, Nashaat N., et al. “Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings.J Psychiatr Res, vol. 39, no. 3, May 2005, pp. 295–302. Pubmed, doi:10.1016/j.jpsychires.2004.07.002.
Boutros NN, Lisanby SH, McClain-Furmanski D, Oliwa G, Gooding D, Kosten TR. Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings. J Psychiatr Res. 2005 May;39(3):295–302.
Journal cover image

Published In

J Psychiatr Res

DOI

ISSN

0022-3956

Publication Date

May 2005

Volume

39

Issue

3

Start / End Page

295 / 302

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Skull
  • Psychiatry
  • Personality Disorders
  • Motor Cortex
  • Middle Aged
  • Male
  • Magnetics
  • MMPI
  • Humans