Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys.

Journal Article (Journal Article)

The hypothesis of cerebellar learning proposes that complex spikes in Purkinje cells engage mechanisms of plasticity in the cerebellar cortex; in turn, changes in the cerebellum depress the simple-spike response of Purkinje cells to a given stimulus and cause the adaptive modification of a motor behavior. Many elements of this hypothesis have been supported by prior experiments, and correlations have been found [corrected] between complex spikes, simple-spike plasticity and behavior [corrected] during the learning process. We carried out a trial-by-trial analysis of Purkinje cell responses in awake-behaving monkeys and found evidence for a causal role for complex spikes in the induction of cerebellar plasticity during a simple motor learning task. We found that the presence of a complex spike on one learning trial was linked to a substantial depression of simple-spike responses on the subsequent trial, at a time when behavioral learning was expressed.

Full Text

Duke Authors

Cited Authors

  • Medina, JF; Lisberger, SG

Published Date

  • October 2008

Published In

Volume / Issue

  • 11 / 10

Start / End Page

  • 1185 - 1192

PubMed ID

  • 18806784

Pubmed Central ID

  • PMC2577564

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/nn.2197


  • eng

Conference Location

  • United States