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Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys.

Publication ,  Journal Article
Medina, JF; Lisberger, SG
Published in: Nat Neurosci
October 2008

The hypothesis of cerebellar learning proposes that complex spikes in Purkinje cells engage mechanisms of plasticity in the cerebellar cortex; in turn, changes in the cerebellum depress the simple-spike response of Purkinje cells to a given stimulus and cause the adaptive modification of a motor behavior. Many elements of this hypothesis have been supported by prior experiments, and correlations have been found [corrected] between complex spikes, simple-spike plasticity and behavior [corrected] during the learning process. We carried out a trial-by-trial analysis of Purkinje cell responses in awake-behaving monkeys and found evidence for a causal role for complex spikes in the induction of cerebellar plasticity during a simple motor learning task. We found that the presence of a complex spike on one learning trial was linked to a substantial depression of simple-spike responses on the subsequent trial, at a time when behavioral learning was expressed.

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Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

October 2008

Volume

11

Issue

10

Start / End Page

1185 / 1192

Location

United States

Related Subject Headings

  • Wakefulness
  • Time Factors
  • Saccades
  • Purkinje Cells
  • Probability
  • Photic Stimulation
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Motor Activity
  • Motion Perception
 

Citation

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Medina, J. F., & Lisberger, S. G. (2008). Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys. Nat Neurosci, 11(10), 1185–1192. https://doi.org/10.1038/nn.2197
Medina, Javier F., and Stephen G. Lisberger. “Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys.Nat Neurosci 11, no. 10 (October 2008): 1185–92. https://doi.org/10.1038/nn.2197.
Medina, Javier F., and Stephen G. Lisberger. “Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys.Nat Neurosci, vol. 11, no. 10, Oct. 2008, pp. 1185–92. Pubmed, doi:10.1038/nn.2197.

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

October 2008

Volume

11

Issue

10

Start / End Page

1185 / 1192

Location

United States

Related Subject Headings

  • Wakefulness
  • Time Factors
  • Saccades
  • Purkinje Cells
  • Probability
  • Photic Stimulation
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Motor Activity
  • Motion Perception