Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys.
Published
Journal Article
The hypothesis of cerebellar learning proposes that complex spikes in Purkinje cells engage mechanisms of plasticity in the cerebellar cortex; in turn, changes in the cerebellum depress the simple-spike response of Purkinje cells to a given stimulus and cause the adaptive modification of a motor behavior. Many elements of this hypothesis have been supported by prior experiments, and correlations have been found [corrected] between complex spikes, simple-spike plasticity and behavior [corrected] during the learning process. We carried out a trial-by-trial analysis of Purkinje cell responses in awake-behaving monkeys and found evidence for a causal role for complex spikes in the induction of cerebellar plasticity during a simple motor learning task. We found that the presence of a complex spike on one learning trial was linked to a substantial depression of simple-spike responses on the subsequent trial, at a time when behavioral learning was expressed.
Full Text
Duke Authors
Cited Authors
- Medina, JF; Lisberger, SG
Published Date
- October 2008
Published In
Volume / Issue
- 11 / 10
Start / End Page
- 1185 - 1192
PubMed ID
- 18806784
Pubmed Central ID
- 18806784
Electronic International Standard Serial Number (EISSN)
- 1546-1726
Digital Object Identifier (DOI)
- 10.1038/nn.2197
Language
- eng
Conference Location
- United States