FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria.

Published

Journal Article

Molecular biomarker has been proposed to improve patient selection and post-transplant prognostication, but rare achievement has been made. In the present study, Forkhead box M1 (FOXM1) expression and its prognostic role have been investigated in hepatocellular carcinoma (HCC) treated by orthotopic liver transplantation (OLT). We found that the notably higher level of FOXM1 in tumors was associated with malignant pathological features of HCC and unfavorable outcome after OLT. The status of FOXM1 expression combined with the Milan criteria could make the prognostication more accurate and may be of particular interest for expanding the criteria in selecting transplant candidates.

Full Text

Duke Authors

Cited Authors

  • Sun, H; Teng, M; Liu, J; Jin, D; Wu, J; Yan, D; Fan, J; Qin, X; Tang, H; Peng, Z

Published Date

  • July 2011

Published In

Volume / Issue

  • 306 / 2

Start / End Page

  • 214 - 222

PubMed ID

  • 21482449

Pubmed Central ID

  • 21482449

Electronic International Standard Serial Number (EISSN)

  • 1872-7980

International Standard Serial Number (ISSN)

  • 0304-3835

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2011.03.009

Language

  • eng