Selective inhibitors of death in mutant huntingtin cells.


Journal Article

Huntington disease (HD) is an inherited neurodegenerative disorder with unclear pathophysiology. We developed a high-throughput assay in a neuronal cell culture model of HD, screened 43,685 compounds and identified 29 novel selective inhibitors of cell death in mutant huntingtin-expressing cells. Four compounds were active in diverse HD models, which suggests a role for cell death in HD; these compounds are mechanistic probes and potential drug leads for HD.

Full Text

Cited Authors

  • Varma, H; Voisine, C; DeMarco, CT; Cattaneo, E; Lo, DC; Hart, AC; Stockwell, BR

Published Date

  • February 2007

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 99 - 100

PubMed ID

  • 17195849

Pubmed Central ID

  • 17195849

Electronic International Standard Serial Number (EISSN)

  • 1552-4469

International Standard Serial Number (ISSN)

  • 1552-4450

Digital Object Identifier (DOI)

  • 10.1038/nchembio852


  • eng