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The DNA damage response in viral-induced cellular transformation.

Publication ,  Journal Article
Nikitin, PA; Luftig, MA
Published in: Br J Cancer
January 31, 2012

The DNA damage response (DDR) has emerged as a critical tumour suppressor pathway responding to cellular DNA replicative stress downstream of aberrant oncogene over-expression. Recent studies have now implicated the DDR as a sensor of oncogenic virus infection. In this review, we discuss the mechanisms by which tumour viruses activate and also suppress the host DDR. The mechanism of tumour virus induction of the DDR is intrinsically linked to the need for these viruses to promote an S-phase environment to replicate their nucleic acid during infection. However, inappropriate expression of viral oncoproteins can also activate the DDR through various mechanisms including replicative stress, direct interaction with DDR components and induction of reactive oxygen species. Given the growth-suppressive consequences of activating the DDR, tumour viruses have also evolved mechanisms to attenuate these pathways. Aberrant expression of viral oncoproteins may therefore promote tumourigenesis through increased somatic mutation and aneuploidy due to DDR inactivation. This review will focus on the interplay between oncogenic viruses and the DDR with respect to cellular checkpoint control and transformation.

Duke Scholars

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Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

January 31, 2012

Volume

106

Issue

3

Start / End Page

429 / 435

Location

England

Related Subject Headings

  • Tumor Virus Infections
  • Oncology & Carcinogenesis
  • Oncogenic Viruses
  • Humans
  • Genes, cdc
  • DNA Damage
  • Cell Transformation, Viral
  • Cell Transformation, Neoplastic
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services
 

Citation

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Nikitin, P. A., & Luftig, M. A. (2012). The DNA damage response in viral-induced cellular transformation. Br J Cancer, 106(3), 429–435. https://doi.org/10.1038/bjc.2011.612
Nikitin, P. A., and M. A. Luftig. “The DNA damage response in viral-induced cellular transformation.Br J Cancer 106, no. 3 (January 31, 2012): 429–35. https://doi.org/10.1038/bjc.2011.612.
Nikitin PA, Luftig MA. The DNA damage response in viral-induced cellular transformation. Br J Cancer. 2012 Jan 31;106(3):429–35.
Nikitin, P. A., and M. A. Luftig. “The DNA damage response in viral-induced cellular transformation.Br J Cancer, vol. 106, no. 3, Jan. 2012, pp. 429–35. Pubmed, doi:10.1038/bjc.2011.612.
Nikitin PA, Luftig MA. The DNA damage response in viral-induced cellular transformation. Br J Cancer. 2012 Jan 31;106(3):429–435.

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

January 31, 2012

Volume

106

Issue

3

Start / End Page

429 / 435

Location

England

Related Subject Headings

  • Tumor Virus Infections
  • Oncology & Carcinogenesis
  • Oncogenic Viruses
  • Humans
  • Genes, cdc
  • DNA Damage
  • Cell Transformation, Viral
  • Cell Transformation, Neoplastic
  • 3211 Oncology and carcinogenesis
  • 1117 Public Health and Health Services