At a crossroads: human DNA tumor viruses and the host DNA damage response.

Journal Article (Journal Article)

Human DNA tumor viruses induce host cell proliferation in order to establish the necessary cellular milieu to replicate viral DNA. The consequence of such viral-programmed induction of proliferation coupled with the introduction of foreign replicating DNA structures makes these viruses particularly sensitive to the host DNA damage response machinery. In fact, sensors of DNA damage are often activated and modulated by DNA tumor viruses in both latent and lytic infection. This article focuses on the role of the DNA damage response during the life cycle of human DNA tumor viruses, with a particular emphasis on recent advances in our understanding of the role of the DNA damage response in EBV, Kaposi's sarcoma-associated herpesvirus and human papillomavirus infection.

Full Text

Duke Authors

Cited Authors

  • Nikitin, PA; Luftig, MA

Published Date

  • July 2011

Published In

Volume / Issue

  • 6 / 7

Start / End Page

  • 813 - 830

PubMed ID

  • 21927617

Pubmed Central ID

  • PMC3171950

International Standard Serial Number (ISSN)

  • 1746-0794

Digital Object Identifier (DOI)

  • 10.2217/fvl.11.55


  • eng

Conference Location

  • England