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Schwann cell influence on motor neuron regeneration accuracy.

Publication ,  Journal Article
Madison, RD; Sofroniew, MV; Robinson, GA
Published in: Neuroscience
September 29, 2009

Extensive peripheral nerve injuries can result in the effective paralysis of the entire limb or distal portions of the limb. The major determinant of functional recovery after lesions in the peripheral nervous system is the accurate regeneration of axons to their original target end-organs. We used the mouse femoral nerve as a model to study motor neuron regeneration accuracy in terms of regenerating motor neurons projecting to their original terminal pathway to quadriceps muscle vs. the inappropriate pathway to skin. Using a variety of surgical manipulations and the selective removal of Schwann cells in the distal nerve via molecular targeting, we have examined the respective roles of end-organ influence (muscle) vs. Schwann cells in this model system. We found evidence of a hierarchy of trophic support that regulates motor neuron regeneration accuracy with muscle contact being the most potent, followed by the number or density of Schwann cells in the distal nerve branches. Manipulating the relative levels of these sources of influence resulted in predictable projection patterns of motor neurons into the terminal pathway either to skin or to muscle.

Duke Scholars

Published In

Neuroscience

DOI

EISSN

1873-7544

Publication Date

September 29, 2009

Volume

163

Issue

1

Start / End Page

213 / 221

Location

United States

Related Subject Headings

  • Thymidine Kinase
  • Skin
  • Sialic Acids
  • Sciatic Neuropathy
  • Schwann Cells
  • Recovery of Function
  • Quadriceps Muscle
  • Neurology & Neurosurgery
  • Neural Cell Adhesion Molecule L1
  • Nerve Regeneration
 

Citation

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ICMJE
MLA
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Madison, R. D., Sofroniew, M. V., & Robinson, G. A. (2009). Schwann cell influence on motor neuron regeneration accuracy. Neuroscience, 163(1), 213–221. https://doi.org/10.1016/j.neuroscience.2009.05.073
Madison, R. D., M. V. Sofroniew, and G. A. Robinson. “Schwann cell influence on motor neuron regeneration accuracy.Neuroscience 163, no. 1 (September 29, 2009): 213–21. https://doi.org/10.1016/j.neuroscience.2009.05.073.
Madison RD, Sofroniew MV, Robinson GA. Schwann cell influence on motor neuron regeneration accuracy. Neuroscience. 2009 Sep 29;163(1):213–21.
Madison, R. D., et al. “Schwann cell influence on motor neuron regeneration accuracy.Neuroscience, vol. 163, no. 1, Sept. 2009, pp. 213–21. Pubmed, doi:10.1016/j.neuroscience.2009.05.073.
Madison RD, Sofroniew MV, Robinson GA. Schwann cell influence on motor neuron regeneration accuracy. Neuroscience. 2009 Sep 29;163(1):213–221.
Journal cover image

Published In

Neuroscience

DOI

EISSN

1873-7544

Publication Date

September 29, 2009

Volume

163

Issue

1

Start / End Page

213 / 221

Location

United States

Related Subject Headings

  • Thymidine Kinase
  • Skin
  • Sialic Acids
  • Sciatic Neuropathy
  • Schwann Cells
  • Recovery of Function
  • Quadriceps Muscle
  • Neurology & Neurosurgery
  • Neural Cell Adhesion Molecule L1
  • Nerve Regeneration