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Optic nerve tissue sections derived from myelin-deficient mutant mice as culture substrata for fibroblast adhesion and spreading.

Publication ,  Journal Article
Kljavin, IJ; Madison, RD; Reh, TA
Published in: Exp Cell Res
May 1991

The substrate properties were compared between normal and myelin-deficient central nervous system (CNS) tissues by an in vitro assay of cell attachment and spreading. Fibroblasts (3T3) were plated onto culture substrata consisting of optic nerve tissue sections cut from normal or two myelin-deficient mutant mice, Shiverer and Quaking. Optic nerve sections from either of the mutant animals supported more 3T3 fibroblast spreading and adhesion than sections derived from animals with normal myelin. These results demonstrate that CNS myelin influences the ability of cells to attach and spread and that it is the actual presence of myelin which is inhibitory rather than the presence of optic nerve axons or oligodendrocytes.

Duke Scholars

Published In

Exp Cell Res

DOI

ISSN

0014-4827

Publication Date

May 1991

Volume

194

Issue

1

Start / End Page

135 / 138

Location

United States

Related Subject Headings

  • Optic Nerve
  • Myelin Sheath
  • Mice, Quaking
  • Mice
  • Fibroblasts
  • Cells, Cultured
  • Cell Movement
  • Cell Communication
  • Cell Adhesion
  • Biochemistry & Molecular Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kljavin, I. J., Madison, R. D., & Reh, T. A. (1991). Optic nerve tissue sections derived from myelin-deficient mutant mice as culture substrata for fibroblast adhesion and spreading. Exp Cell Res, 194(1), 135–138. https://doi.org/10.1016/0014-4827(91)90142-h
Kljavin, I. J., R. D. Madison, and T. A. Reh. “Optic nerve tissue sections derived from myelin-deficient mutant mice as culture substrata for fibroblast adhesion and spreading.Exp Cell Res 194, no. 1 (May 1991): 135–38. https://doi.org/10.1016/0014-4827(91)90142-h.
Kljavin, I. J., et al. “Optic nerve tissue sections derived from myelin-deficient mutant mice as culture substrata for fibroblast adhesion and spreading.Exp Cell Res, vol. 194, no. 1, May 1991, pp. 135–38. Pubmed, doi:10.1016/0014-4827(91)90142-h.
Journal cover image

Published In

Exp Cell Res

DOI

ISSN

0014-4827

Publication Date

May 1991

Volume

194

Issue

1

Start / End Page

135 / 138

Location

United States

Related Subject Headings

  • Optic Nerve
  • Myelin Sheath
  • Mice, Quaking
  • Mice
  • Fibroblasts
  • Cells, Cultured
  • Cell Movement
  • Cell Communication
  • Cell Adhesion
  • Biochemistry & Molecular Biology