Acidic fibroblast growth factor enhances peripheral nerve regeneration in vivo.

Journal Article (Journal Article)

When added to a collagen-filled nerve guide, purified acidic fibroblast growth factor (aFGF) increased the number of myelinated axons that regenerated across a 5-mm nerve gap distance. In addition, a greater number of primary sensory and motor neurons extended axons through the nerve guide in animals treated with aFGF. Thus the effect of aFGF on peripheral nerve regeneration is not simply an increase in axonal branching within the nerve guide tube. This is the first highly purified growth factor since nerve growth factor that has been shown to promote nerve regeneration in vivo. This experimental model provides a convenient and quantitative means to assess the effects of putative neuronotropic factors on peripheral nerve regeneration in vivo.

Full Text

Duke Authors

Cited Authors

  • Cordeiro, PG; Seckel, BR; Lipton, SA; D'Amore, PA; Wagner, J; Madison, R

Published Date

  • June 1989

Published In

Volume / Issue

  • 83 / 6

Start / End Page

  • 1013 - 1019

PubMed ID

  • 2727148

International Standard Serial Number (ISSN)

  • 0032-1052


  • eng

Conference Location

  • United States