Retinal ganglion cells and axons survive optic nerve transection.

Journal Article (Journal Article)

The effects of optic nerve transection on optic axon and retinal cell survival was studied in C57BL/6J mice. The optic nerve was transected either intracranially or intraorbitally . Data are presented which show that an intracranial transection of the optic nerve may be achieved while maintaining the blood supply to the retina. Intraorbital optic nerve transection, however, necessitates destruction of the retinal blood supply. Cell survival in the retinal ganglion cell layer is compared for both transection methods. In addition, electron microscopic evidence is presented which indicates axonal survival in the optic nerve up to at least 90 days following intracranial transection.

Full Text

Duke Authors

Cited Authors

  • Madison, R; Moore, MR; Sidman, RL

Published Date

  • March 1, 1984

Published In

Volume / Issue

  • 23 / 1

Start / End Page

  • 15 - 32

PubMed ID

  • 6724814

International Standard Serial Number (ISSN)

  • 0020-7454

Digital Object Identifier (DOI)

  • 10.3109/00207458408985342


  • eng

Conference Location

  • England