Peripheral nerve repair with bioresorbable prosthesis.

Journal Article (Journal Article)

Using the transected sciatic nerve model in adult mice, regeneration of a large bundle of axons organized into the form of a nerve with myelinated and unmyelinated axons, Schwann cells, fibroblasts, collagen, blood vessels, and connective tissue sheaths has been achieved with bioresorbable microtubular guidance channels over gaps of 5 mm in nonimmobilized animals. After 4-6 wks postoperatively, the regenerated nerve cable contains on the order of 40% as many myelinated axons as were measured in the proximal nerve stumps. With the channels used so far in this model, regenerating axons pass into the distal stump in about 3-6 wks postoperatively. The guidance channels used consist of synthetic polyesters and/or polyester composites including glycolic and lactic acid polymers, and polyesters derived from Krebs Cycle dicarboxylic acids. Inflammatory response to these materials has been minimal. Biodegradation/resorption rates can be controlled so as to be compatible with axon growth rates.

Full Text

Duke Authors

Cited Authors

  • Nyilas, E; Chiu, TH; Sidman, RL; Henry, EW; Brushart, TM; Dikkes, P; Madison, R

Published Date

  • 1983

Published In

Volume / Issue

  • 29 /

Start / End Page

  • 307 - 313

PubMed ID

  • 6673245

International Standard Serial Number (ISSN)

  • 0066-0078


  • eng

Conference Location

  • United States