T wave alternans: a marker of myocardial instability.

Journal Article (Review;Journal Article)

T wave alternans is an electrocardiographic marker of myocardial electrical instability considered predictive for the development of lethal ventricular rhythms. Direct observation of this phenomenon on the electrocardiogram is rare. Subtle, nonvisible alternation of the T wave may be detected at the microvolt level using advanced signal processing techniques. This technology has enabled investigators and clinicians to identify and risk-stratify certain groups at high risk for sudden cardiac death. The purpose of this review is to discuss the concept of T wave alternans in relation to all cardiac alternans, provide an overview of its proposed mechanisms, and address the clinical utility of this electrocardiographic marker of myocardial electrical instability.

Full Text

Duke Authors

Cited Authors

  • Harvey, M; Malkin, R

Published Date

  • January 2003

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 99 - 111

PubMed ID

  • 12732803

Pubmed Central ID

  • 12732803

Electronic International Standard Serial Number (EISSN)

  • 1751-7117

International Standard Serial Number (ISSN)

  • 0889-7204

Digital Object Identifier (DOI)

  • 10.1111/j.0889-7204.2006.01852.x


  • eng