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Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls.

Publication ,  Journal Article
Mannelli, P; Patkar, AA; Peindl, K; Tharwani, H; Gopalakrishnan, R; Hill, KP; Berrettini, WH
Published in: Psychiatry Res
November 15, 2006

Serotonin (5-HT) function is altered in several psychiatric disorders, including cocaine dependence (CD), and its role in impulsive-aggressive behaviors has been widely studied. However, the relationship between psychopathological and behavioral dimensions and mechanisms of 5-HT alterations remains unclear. We investigated the relationship of a polymorphism in the 5' promoter region of the serotonin transporter gene (5-HTTLPR) with prolactin (PRL) response to meta-chlorophenylpiperazine (m-CPP) in a sample of 68 African-American individuals, 35 CD subjects and 33 controls. We also examined whether measures of impulsivity, hostility and sensation seeking influenced the relationship between the 5-HTTLPR polymorphism and PRL response to m-CPP in this sample. Individuals with the SS genotype showed significantly heightened PRL response to the challenge compared with the LL and LS genotypes. No influence of gender or substance abuse condition was observed. Hostility was associated with blunted PRL response in the total sample. Cocaine abuse was the most significant moderator of DeltaPRL (peak PRL-baseline PRL), and the interaction of genetic, behavioral and psychopathological measures helped predict most of the observed DeltaPRL (62.5%). Although these results need replication, variation in the 5-HTTLPR gene appears to influence measures of 5-HT function and interact with disease state and personality dimensions to account for 5-HT disturbances in African-American populations.

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Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

November 15, 2006

Volume

144

Issue

2-3

Start / End Page

99 / 108

Location

Ireland

Related Subject Headings

  • Surveys and Questionnaires
  • Serotonin Receptor Agonists
  • Serotonin Plasma Membrane Transport Proteins
  • Psychiatry
  • Promoter Regions, Genetic
  • Prolactin
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Piperazines
  • Male
 

Citation

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MLA
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Mannelli, P., Patkar, A. A., Peindl, K., Tharwani, H., Gopalakrishnan, R., Hill, K. P., & Berrettini, W. H. (2006). Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls. Psychiatry Res, 144(2–3), 99–108. https://doi.org/10.1016/j.psychres.2006.01.012
Mannelli, Paolo, Ashwin A. Patkar, Kathleen Peindl, Haresh Tharwani, Raman Gopalakrishnan, Kevin P. Hill, and Wade H. Berrettini. “Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls.Psychiatry Res 144, no. 2–3 (November 15, 2006): 99–108. https://doi.org/10.1016/j.psychres.2006.01.012.
Mannelli P, Patkar AA, Peindl K, Tharwani H, Gopalakrishnan R, Hill KP, et al. Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls. Psychiatry Res. 2006 Nov 15;144(2–3):99–108.
Mannelli, Paolo, et al. “Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls.Psychiatry Res, vol. 144, no. 2–3, Nov. 2006, pp. 99–108. Pubmed, doi:10.1016/j.psychres.2006.01.012.
Mannelli P, Patkar AA, Peindl K, Tharwani H, Gopalakrishnan R, Hill KP, Berrettini WH. Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls. Psychiatry Res. 2006 Nov 15;144(2–3):99–108.
Journal cover image

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

November 15, 2006

Volume

144

Issue

2-3

Start / End Page

99 / 108

Location

Ireland

Related Subject Headings

  • Surveys and Questionnaires
  • Serotonin Receptor Agonists
  • Serotonin Plasma Membrane Transport Proteins
  • Psychiatry
  • Promoter Regions, Genetic
  • Prolactin
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Piperazines
  • Male