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Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals.

Publication ,  Journal Article
Mannelli, P; Patkar, AA; Murray, HW; Certa, K; Peindl, K; Mattila-Evenden, M; Berrettini, WH
Published in: Addict Biol
September 2005

The serotonin transporter (5-HTT) regulates serotonin transmission and modulates behavioral effects of drug of abuse. A polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) yielding a short (S) and long (L) allele has been associated with severity of substance abuse. The aims of the study were to investigate whether 5-HTTLPR genotypes differed in their response to treatment in cocaine- and alcohol-abusing patients. Polymerase chain reaction-based genotyping of a 44 base pair insertion/deletion polymorphism was performed in 141 African American cocaine-dependent patients with concurrent alcohol use who were entering a 12-week behaviorally oriented outpatient treatment program. In treatment, end of treatment and 6-month follow-up outcome measures included changes in Addiction Severity Index (ASI) scores, urine drug screens, days in treatment, individual/group sessions, dropout and completion rates. As expected, there was a reduction in substance abuse by the end of treatment and follow-up (F = 5.15, p = 0.000). However, there were no differences in the reduction in cocaine use across the LL, LS and SS genotypes. Interestingly, individuals with the S allele showed greater severity of alcohol use at admission (F = 4.84, p = 0.03), and the SS genotype showed less improvement in alcohol measures than the LL at follow-up (F = 3.68, p = 0.03), after controlling for baseline variables. While we found no association of the 5-HTTLPR variants with severity of cocaine abuse or any cocaine-related outcome measures, the data suggested that the 5-HTTLPR polymorphism may distinguish responders from non-responders to behavioral treatment in terms of alcohol use. Further investigations are required to determine the role of the 5-HTTLPR polymorphism in influencing treatment - outcome among substance abusers.

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Published In

Addict Biol

DOI

ISSN

1355-6215

Publication Date

September 2005

Volume

10

Issue

3

Start / End Page

261 / 268

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Substance Abuse
  • Severity of Illness Index
  • Serotonin Plasma Membrane Transport Proteins
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Male
  • Humans
  • Genotype
  • Genes, Reporter
 

Citation

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Mannelli, P., Patkar, A. A., Murray, H. W., Certa, K., Peindl, K., Mattila-Evenden, M., & Berrettini, W. H. (2005). Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals. Addict Biol, 10(3), 261–268. https://doi.org/10.1080/13556210500235540
Mannelli, Paolo, Ashwin A. Patkar, Heather W. Murray, Kenneth Certa, Kathleen Peindl, Marja Mattila-Evenden, and Wade H. Berrettini. “Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals.Addict Biol 10, no. 3 (September 2005): 261–68. https://doi.org/10.1080/13556210500235540.
Mannelli P, Patkar AA, Murray HW, Certa K, Peindl K, Mattila-Evenden M, et al. Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals. Addict Biol. 2005 Sep;10(3):261–8.
Mannelli, Paolo, et al. “Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals.Addict Biol, vol. 10, no. 3, Sept. 2005, pp. 261–68. Pubmed, doi:10.1080/13556210500235540.
Mannelli P, Patkar AA, Murray HW, Certa K, Peindl K, Mattila-Evenden M, Berrettini WH. Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals. Addict Biol. 2005 Sep;10(3):261–268.
Journal cover image

Published In

Addict Biol

DOI

ISSN

1355-6215

Publication Date

September 2005

Volume

10

Issue

3

Start / End Page

261 / 268

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Substance Abuse
  • Severity of Illness Index
  • Serotonin Plasma Membrane Transport Proteins
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Male
  • Humans
  • Genotype
  • Genes, Reporter