Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine.

Journal Article (Clinical Trial;Journal Article)

Thirty-nine methadone maintenance patients were included in a 9-day, double blind, randomized, inpatient detoxification trial. Methadone was tapered to 10 mg/day and then patients were assigned to one of these 3 protocols: clonidine (0.3-0.9 mg/day), lefetamine (60-240 mg/day), buprenorphine (0.15-0.9 mg/day). Buprenorphine treatment was significantly superior to clonidine and to lefetamine (F = 3.96 df = 2, 29 P < 0.05) in controlling objective, subjective and psychological withdrawal symptomatology. Clonidine was more effective than lefetamine in suppressing withdrawal in the first 3 days of treatment (day 3: F = 4.10 df = 2, 30 P < 0.05), and this trend was apparent on the objective and psychological items. In addition to evaluations of the efficacy of the single drugs used, the study showed that tapering methadone to low doses before entering the pharmacologically assisted discontinuation phase was clinically acceptable in detoxification from long-term methadone treatment.

Full Text

Duke Authors

Cited Authors

  • Janiri, L; Mannelli, P; Persico, AM; Serretti, A; Tempesta, E

Published Date

  • October 1994

Published In

Volume / Issue

  • 36 / 2

Start / End Page

  • 139 - 145

PubMed ID

  • 7851281

International Standard Serial Number (ISSN)

  • 0376-8716

Digital Object Identifier (DOI)

  • 10.1016/0376-8716(94)90096-5


  • eng

Conference Location

  • Ireland