Zipeprol is a newly abused antitussive with an opioid spectrum and hallucinogenic effects.

Journal Article (Journal Article)

Zipeprol is a non-opioid cough suppressor agent recently abused in Italy. Clinical reports from 30 street abusers show that the drug in high doses has a definite abuse liability and dependence potential. Many of its effects were identical to those induced by opiates, although specific dysperceptive symptoms were commonly reported by patients. Spontaneous withdrawal symptoms were similar to those of opiates. Withdrawal could be also precipitated by naloxone. It is concluded that zipeprol can induce dependence with a mechanism which may be mediated by some types of opioid receptors.

Full Text

Duke Authors

Cited Authors

  • Janiri, L; Mannelli, P; Persico, AM; Diodato, S; Tempesta, E

Published Date

  • March 1, 1991

Published In

Volume / Issue

  • 27 / 2

Start / End Page

  • 121 - 125

PubMed ID

  • 2055160

International Standard Serial Number (ISSN)

  • 0376-8716

Digital Object Identifier (DOI)

  • 10.1016/0376-8716(91)90030-3


  • eng

Conference Location

  • Ireland