Lephetamine abuse and dependence: clinical effects and withdrawal syndrome.

Journal Article (Journal Article)

Lephetamine (L-SPA) is a compound with central analgesic and anti-inflammatory action, recently reported to be abused in Italy. In this study, cases of L-SPA abuse were recorded. The survey included 15 patients who were assessed for effects caused by using L-SPA and induced by withdrawal. Moreover L-SPA was administered to 15 volunteers. L-SPA displayed effects partly similar to opiates and its withdrawal caused both subjective and objective symptoms. It is concluded that L-SPA exhibits abuse liability and dependence potential of a certain degree.

Full Text

Duke Authors

Cited Authors

  • Janiri, L; Mannelli, P; Pirrongelli, C; Lo Monaco, M; Tempesta, E

Published Date

  • January 1989

Published In

Volume / Issue

  • 84 / 1

Start / End Page

  • 89 - 95

PubMed ID

  • 2917208

International Standard Serial Number (ISSN)

  • 0952-0481

Digital Object Identifier (DOI)

  • 10.1111/j.1360-0443.1989.tb00555.x


  • eng

Conference Location

  • England