Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity.


Journal Article

Lefetamine (SPA) combining amphetamine with opioid-like effects, a drug of wide abuse in Japan in the fifties, has now been introduced as such in Italy. In this study the drug was tested to verify its resemblance to opiates. Ten lefetamine abusers were hospitalized and then subjected to naloxone- and pentazocine-tests and detoxified. Moreover, lefetamine was administered to ten opiate addicts with an acute withdrawal syndrome and to ten methadone-treated addicts. The naloxone-test was positive and pentazocine could be substituted for lefetamine. Lefetamine was able to relieve opiate withdrawal and did not precipitate withdrawal symptoms in stabilized opiate addicts. It is concluded that lefetamine may act as an opioid partial agonist.

Full Text

Duke Authors

Cited Authors

  • Mannelli, P; Janiri, L; De Marinis, M; Tempesta, E

Published Date

  • October 1989

Published In

Volume / Issue

  • 24 / 2

Start / End Page

  • 95 - 101

PubMed ID

  • 2571492

Pubmed Central ID

  • 2571492

International Standard Serial Number (ISSN)

  • 0376-8716

Digital Object Identifier (DOI)

  • 10.1016/0376-8716(89)90071-9


  • eng

Conference Location

  • Ireland