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Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy.

Publication ,  Journal Article
Skavdahl, M; Steenbergen, C; Clark, J; Myers, P; Demianenko, T; Mao, L; Rockman, HA; Korach, KS; Murphy, E
Published in: Am J Physiol Heart Circ Physiol
February 2005

The goal of this study was to determine the role of estrogen receptor subtypes in the development of pressure overload hypertrophy in mice. Epidemiological studies have suggested gender differences in the development of hypertrophy and heart disease, but the mechanism and the role of estrogen receptor subtypes are not established. We performed transverse aortic constriction (TAC) and sham operations in male and female wild-type (WT) mice and mice lacking functional estrogen receptor-alpha [alpha-estrogen receptor knockout (alpha-ERKO)] and mice lacking estrogen receptor-beta (beta-ERKO). Body, heart, and lung weights were measured 2 wk postsurgery. WT male mice subjected to TAC showed a 64% increase in the heart weight-to-body weight ratio (HW/BW) compared with sham, and WT males have increased lung weight at 2 wk. WT female mice subjected to TAC showed a 31% increase in HW/BW compared with sham, which was significantly less than their male counterparts and with no evidence of heart failure. alpha-ERKO females developed HW/BW nearly identical to that seen in WT littermate females in response to TAC, indicating that estrogen receptor-alpha is not essential for the attenuation of hypertrophy observed in WT females. In contrast, beta-ERKO females responded to TAC with a significantly greater increase in HW/BW than WT littermate females. beta-ERKO females have lower expression of lipoprotein lipase at baseline than WT or alpha-ERKO females. These data suggest an important role for estrogen receptor-beta in attenuating the hypertrophic response to pressure overload in females.

Duke Scholars

Published In

Am J Physiol Heart Circ Physiol

DOI

ISSN

0363-6135

Publication Date

February 2005

Volume

288

Issue

2

Start / End Page

H469 / H476

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Pressure
  • Organ Size
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Ligation
  • Female
  • Estrogen Receptor beta
 

Citation

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Chicago
ICMJE
MLA
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Skavdahl, M., Steenbergen, C., Clark, J., Myers, P., Demianenko, T., Mao, L., … Murphy, E. (2005). Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. Am J Physiol Heart Circ Physiol, 288(2), H469–H476. https://doi.org/10.1152/ajpheart.00723.2004
Skavdahl, Maryanne, Charles Steenbergen, James Clark, Page Myers, Tracy Demianenko, Lan Mao, Howard A. Rockman, Kenneth S. Korach, and Elizabeth Murphy. “Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy.Am J Physiol Heart Circ Physiol 288, no. 2 (February 2005): H469–76. https://doi.org/10.1152/ajpheart.00723.2004.
Skavdahl M, Steenbergen C, Clark J, Myers P, Demianenko T, Mao L, et al. Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H469–76.
Skavdahl, Maryanne, et al. “Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy.Am J Physiol Heart Circ Physiol, vol. 288, no. 2, Feb. 2005, pp. H469–76. Pubmed, doi:10.1152/ajpheart.00723.2004.
Skavdahl M, Steenbergen C, Clark J, Myers P, Demianenko T, Mao L, Rockman HA, Korach KS, Murphy E. Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H469–H476.

Published In

Am J Physiol Heart Circ Physiol

DOI

ISSN

0363-6135

Publication Date

February 2005

Volume

288

Issue

2

Start / End Page

H469 / H476

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Pressure
  • Organ Size
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Ligation
  • Female
  • Estrogen Receptor beta