Assessing medication effects in the MTA study using neuropsychological outcomes.

Journal Article (Clinical Trial;Journal Article)

BACKGROUND: While studies have increasingly investigated deficits in reaction time (RT) and RT variability in children with attention deficit/hyperactivity disorder (ADHD), few studies have examined the effects of stimulant medication on these important neuropsychological outcome measures. METHODS: 316 children who participated in the Multimodal Treatment Study of Children with ADHD (MTA) completed the Conners' Continuous Performance Test (CPT) at the 24-month assessment point. Outcome measures included standard CPT outcomes (e.g., errors of commission, mean hit reaction time (RT)) and RT indicators derived from an Ex-Gaussian distributional model (i.e., mu, sigma, and tau). RESULTS: Analyses revealed significant effects of medication across all neuropsychological outcome measures. Results on the Ex-Gaussian outcome measures revealed that stimulant medication slows RT and reduces RT variability. CONCLUSIONS: This demonstrates the importance of including analytic strategies that can accurately model the actual distributional pattern, including the positive skew. Further, the results of the study relate to several theoretical models of ADHD.

Full Text

Duke Authors

Cited Authors

  • Epstein, JN; Conners, CK; Hervey, AS; Tonev, ST; Arnold, LE; Abikoff, HB; Elliott, G; Greenhill, LL; Hechtman, L; Hoagwood, K; Hinshaw, SP; Hoza, B; Jensen, PS; March, JS; Newcorn, JH; Pelham, WE; Severe, JB; Swanson, JM; Wells, K; Vitiello, B; Wigal, T; MTA Cooperative Study Group,

Published Date

  • May 2006

Published In

Volume / Issue

  • 47 / 5

Start / End Page

  • 446 - 456

PubMed ID

  • 16671928

International Standard Serial Number (ISSN)

  • 0021-9630

Digital Object Identifier (DOI)

  • 10.1111/j.1469-7610.2005.01469.x


  • eng

Conference Location

  • England