Response to methylphenidate in children with attention deficit hyperactivity disorder and manic symptoms in the multimodal treatment study of children with attention deficit hyperactivity disorder titration trial.


Journal Article

OBJECTIVE:Recent reports raise concern that children with attention deficit hyperactivity disorder (ADHD) and some manic symptoms may worsen with stimulant treatment. This study examines the response to methylphenidate in such children. METHODS:Data from children participating in the 1-month methylphenidate titration trial of the Multimodal Treatment Study of Children with ADHD were reanalyzed by dividing the sample into children with and without some manic symptoms. Two "mania proxies" were constructed using items from the Diagnostic Interview Schedule for Children (DISC) or the Child Behavior Checklist (CBCL). Treatment response and side effects are compared between participants with and without proxies. RESULTS:Thirty-two (11%) and 29 (10%) participants fulfilled criteria for the CBCL mania proxy and DISC mania proxy, respectively. Presence or absence of either proxy did not predict a greater or lesser response or side effects. CONCLUSION:Findings suggest that children with ADHD and manic symptoms respond robustly to methylphenidate during the first month of treatment and that these children are not more likely to have an adverse response to methylphenidate. Further research is needed to explore how such children will respond during long-term treatment. Clinicians should not a priori avoid stimulants in children with ADHD and some manic symptoms.

Full Text

Cited Authors

  • Galanter, CA; Carlson, GA; Jensen, PS; Greenhill, LL; Davies, M; Li, W; Chuang, SZ; Elliott, GR; Arnold, LE; March, JS; Hechtman, L; Pelham, WE; Swanson, JM

Published Date

  • January 2003

Published In

Volume / Issue

  • 13 / 2

Start / End Page

  • 123 - 136

PubMed ID

  • 12880507

Pubmed Central ID

  • 12880507

Electronic International Standard Serial Number (EISSN)

  • 1557-8992

International Standard Serial Number (ISSN)

  • 1044-5463

Digital Object Identifier (DOI)

  • 10.1089/104454603322163844


  • eng