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Effect of tumor size and tumor-to-liver contrast of hypovascular liver tumors on the diagnostic performance of hepatic CT imaging.

Publication ,  Journal Article
Schindera, ST; Hareter, LF; Raible, S; Torrente, JC; Rusch, O; Rosskopf, AB; Marin, D; Vock, P; Szucs-Farkas, Z
Published in: Invest Radiol
March 2012

OBJECTIVE: To assess the effect of tumor size and tumor-to-liver contrast of simulated hypovascular liver tumors on the diagnostic accuracy of hepatic computed tomography (CT). MATERIALS AND METHODS: This retrospective study was approved by the institutional review board, and informed consent was waived. A total of 153 simulated hypovascular liver tumors were embedded in 70 hepatic CT data sets that were acquired during the portal venous phase. The simulated tumors had 3 different diameters (6, 10, and 14 mm) and 3 different tumor-to-liver contrast values (20, 35, and 50 HU). There were also 30 hepatic CT data sets without liver tumors. Three radiologists independently performed tumor detection on the randomized 100 hepatic CT data sets. RESULTS: The lowest sensitivity was obtained for the 6-mm tumors with a tumor-to-liver contrast of 20 HU (4.1%), and the highest sensitivity was obtained for the 10- and 14-mm tumors with a tumor-to-liver contrast of 50 HU (100%). Increasing the contrast from 20 to 35 to 50 HU in the 6-mm tumors yielded a significant increase in sensitivity (4.1%, 48.8%, and 92.4%, respectively; P < 0.0001). The sensitivity for the 10- and 14-mm tumors also increased significantly as the tumor-to-liver contrast value increased from 20 to 35 HU (P < 0.01). However, no significant increase in sensitivity was seen for the 10- and 14-mm tumors as the tumor-to-liver contrast values increased from 35 to 50 HU (P = 0.733 and P = 1.0, respectively). CONCLUSIONS: Increasing the tumor-to-liver contrast from 20 to 35 HU results in a significant increase in the detection of hypovascular liver tumors ranging from 6 to 14 mm in diameter. Optimization of the tumor-to-liver contrast is necessary for improved detection of hypovascular liver tumors.

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Published In

Invest Radiol

DOI

EISSN

1536-0210

Publication Date

March 2012

Volume

47

Issue

3

Start / End Page

197 / 201

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Time Factors
  • Statistics as Topic
  • Sensitivity and Specificity
  • Retrospective Studies
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver Neoplasms
 

Citation

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Schindera, S. T., Hareter, L. F., Raible, S., Torrente, J. C., Rusch, O., Rosskopf, A. B., … Szucs-Farkas, Z. (2012). Effect of tumor size and tumor-to-liver contrast of hypovascular liver tumors on the diagnostic performance of hepatic CT imaging. Invest Radiol, 47(3), 197–201. https://doi.org/10.1097/RLI.0b013e3182361dbe
Schindera, Sebastian T., Lisa F. Hareter, Stephan Raible, Jaled Charimo Torrente, Oliver Rusch, Andrea B. Rosskopf, Daniele Marin, Peter Vock, and Zsolt Szucs-Farkas. “Effect of tumor size and tumor-to-liver contrast of hypovascular liver tumors on the diagnostic performance of hepatic CT imaging.Invest Radiol 47, no. 3 (March 2012): 197–201. https://doi.org/10.1097/RLI.0b013e3182361dbe.
Schindera ST, Hareter LF, Raible S, Torrente JC, Rusch O, Rosskopf AB, et al. Effect of tumor size and tumor-to-liver contrast of hypovascular liver tumors on the diagnostic performance of hepatic CT imaging. Invest Radiol. 2012 Mar;47(3):197–201.
Schindera, Sebastian T., et al. “Effect of tumor size and tumor-to-liver contrast of hypovascular liver tumors on the diagnostic performance of hepatic CT imaging.Invest Radiol, vol. 47, no. 3, Mar. 2012, pp. 197–201. Pubmed, doi:10.1097/RLI.0b013e3182361dbe.
Schindera ST, Hareter LF, Raible S, Torrente JC, Rusch O, Rosskopf AB, Marin D, Vock P, Szucs-Farkas Z. Effect of tumor size and tumor-to-liver contrast of hypovascular liver tumors on the diagnostic performance of hepatic CT imaging. Invest Radiol. 2012 Mar;47(3):197–201.

Published In

Invest Radiol

DOI

EISSN

1536-0210

Publication Date

March 2012

Volume

47

Issue

3

Start / End Page

197 / 201

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Time Factors
  • Statistics as Topic
  • Sensitivity and Specificity
  • Retrospective Studies
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Liver Neoplasms