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Hepatocellular carcinoma presenting at contrast-enhanced multi-detector-row computed tomography or gadolinium-enhanced magnetic resonance imaging as a small (≤2 cm), indeterminate nodule: growth rate and optimal interval time for imaging follow-up.

Publication ,  Journal Article
Furlan, A; Marin, D; Agnello, F; Di Martino, M; Di Marco, V; Lagalla, R; Catalano, C; Brancatelli, G
Published in: J Comput Assist Tomogr
2012

OBJECTIVE: The objective of the study was to measure growth rate and to determine the optimal interval time for imaging follow-up of hepatocellular carcinomas (HCCs) presenting at multi-detector-row computed tomography (MDCT) or magnetic resonance imaging (MRI) as small, indeterminate lesions. METHODS: We included patients with cirrhosis with HCC initially presenting as indeterminate lesion of 2 cm or less at MDCT or MRI August 2005 to August 2009 and with available imaging follow-up. Measures of tumor growth included tumor volume doubling time (TVDT), tumor percentual diameter increase, and tumor percentual volume increase. RESULTS: We examined 48 patients (mean age, 64 years) with 69 HCCs. At index examination, mean (SD) maximum transverse diameter and volume of lesions were 1.2 (SD, 0.3) cm and 0.6 (SD, 0.7) cm, respectively. Median TVDT was 210 days. Tumors with follow-up longer than 365 days had significant increase in tumor percentual diameter increase and tumor percentual volume increase. CONCLUSIONS: Median TVDT of 210 days suggests extended follow-up of 6 months for small, indeterminate liver nodules detected at MDCT or MRI.

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Published In

J Comput Assist Tomogr

DOI

EISSN

1532-3145

Publication Date

2012

Volume

36

Issue

1

Start / End Page

20 / 25

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Time Factors
  • Statistics, Nonparametric
  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Liver Cirrhosis
 

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Furlan, A., Marin, D., Agnello, F., Di Martino, M., Di Marco, V., Lagalla, R., … Brancatelli, G. (2012). Hepatocellular carcinoma presenting at contrast-enhanced multi-detector-row computed tomography or gadolinium-enhanced magnetic resonance imaging as a small (≤2 cm), indeterminate nodule: growth rate and optimal interval time for imaging follow-up. J Comput Assist Tomogr, 36(1), 20–25. https://doi.org/10.1097/RCT.0b013e31823ed462
Furlan, Alessandro, Daniele Marin, Francesco Agnello, Michele Di Martino, Vito Di Marco, Roberto Lagalla, Carlo Catalano, and Giuseppe Brancatelli. “Hepatocellular carcinoma presenting at contrast-enhanced multi-detector-row computed tomography or gadolinium-enhanced magnetic resonance imaging as a small (≤2 cm), indeterminate nodule: growth rate and optimal interval time for imaging follow-up.J Comput Assist Tomogr 36, no. 1 (2012): 20–25. https://doi.org/10.1097/RCT.0b013e31823ed462.

Published In

J Comput Assist Tomogr

DOI

EISSN

1532-3145

Publication Date

2012

Volume

36

Issue

1

Start / End Page

20 / 25

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Time Factors
  • Statistics, Nonparametric
  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Liver Cirrhosis