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Multinodular focal fatty infiltration of the liver: atypical imaging findings on delayed T1-weighted Gd-BOPTA-enhanced liver-specific MR images.

Publication ,  Journal Article
Marin, D; Iannaccone, R; Catalano, C; Passariello, R
Published in: J Magn Reson Imaging
September 2006

We report a case of pathologically confirmed multinodular focal fatty infiltration. MRI was performed after bolus injection of gadobenate dimeglumine (Gd-BOPTA, MultiHance; Bracco, Milan, Italy), a liver-specific paramagnetic, gadolinium (Gd)-based MR contrast agent that concomitantly enables the acquisition of a standard dynamic phase with timing strategies similar to those used for other extracellular fluid contrast agents, followed by a delayed T1-weighted liver-specific phase (the so-called hepatobiliary phase). In the present case, multiple rounded areas of fatty infiltration, although confidently diagnosed using chemical shift sequences due to a significant signal intensity reduction on out-of-phase images, were unexpectedly hypointense during the delayed liver-specific phase of Gd-BOPTA. Reduced Gd-BOPTA concentration during the liver-specific phase is generally correlated with liver malignancy. Since such lesions can be prospectively mistaken for metastatic disease, we performed a hepatic biopsy to establish a definitive diagnosis. Our empirical observations suggest that Gd-BOPTA uptake may be impaired in fatty infiltrated liver tissue. Because at present there is no report evaluating the kinetics of Gd-BOPTA in fatty liver, further studies are needed to specifically investigate this issue.

Duke Scholars

Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

September 2006

Volume

24

Issue

3

Start / End Page

690 / 694

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Meglumine
  • Male
  • Magnetic Resonance Imaging
  • Liver
  • Kinetics
  • Image Processing, Computer-Assisted
  • Humans
 

Citation

APA
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ICMJE
MLA
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Marin, D., Iannaccone, R., Catalano, C., & Passariello, R. (2006). Multinodular focal fatty infiltration of the liver: atypical imaging findings on delayed T1-weighted Gd-BOPTA-enhanced liver-specific MR images. J Magn Reson Imaging, 24(3), 690–694. https://doi.org/10.1002/jmri.20660
Marin, Daniele, Riccardo Iannaccone, Carlo Catalano, and Roberto Passariello. “Multinodular focal fatty infiltration of the liver: atypical imaging findings on delayed T1-weighted Gd-BOPTA-enhanced liver-specific MR images.J Magn Reson Imaging 24, no. 3 (September 2006): 690–94. https://doi.org/10.1002/jmri.20660.
Marin D, Iannaccone R, Catalano C, Passariello R. Multinodular focal fatty infiltration of the liver: atypical imaging findings on delayed T1-weighted Gd-BOPTA-enhanced liver-specific MR images. J Magn Reson Imaging. 2006 Sep;24(3):690–4.
Marin, Daniele, et al. “Multinodular focal fatty infiltration of the liver: atypical imaging findings on delayed T1-weighted Gd-BOPTA-enhanced liver-specific MR images.J Magn Reson Imaging, vol. 24, no. 3, Sept. 2006, pp. 690–94. Pubmed, doi:10.1002/jmri.20660.
Marin D, Iannaccone R, Catalano C, Passariello R. Multinodular focal fatty infiltration of the liver: atypical imaging findings on delayed T1-weighted Gd-BOPTA-enhanced liver-specific MR images. J Magn Reson Imaging. 2006 Sep;24(3):690–694.
Journal cover image

Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

September 2006

Volume

24

Issue

3

Start / End Page

690 / 694

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Meglumine
  • Male
  • Magnetic Resonance Imaging
  • Liver
  • Kinetics
  • Image Processing, Computer-Assisted
  • Humans