Polymorphism of human B-cell alloantigens: Evidence for three loci within the HLA system


Journal Article

The B-cell alloantigens of an HLA-DR3-homozygous, MB2-homozygous, MT2-positive lymphoblastoid cell line were studied by two-dimensional gel electrophoresis. Analysis of gel patterns suggested assignment of the HLA-DR3 determinant to the larger (35,000-dalton) subunit (α) of the B-cell alloantigen. MB2 was found to be either a determinant on the small (27,000 dalton) subunit (β) or a crossreactive determinant(s) on the HLA-DR3 α subunit and an additional α subunit, MT2 was found to be a determinant on Ia antigen-like molecules distinct from those carrying the MB and HLA-DR determinants. The results are consistent with the existence in the major histocompatibility complex of at least three loci encoding B-cell alloantigens.

Duke Authors

Cited Authors

  • Markert, ML; Cresswell, P

Published Date

  • December 1, 1980

Published In

Volume / Issue

  • 77 / 10 II

Start / End Page

  • 6101 - 6104

International Standard Serial Number (ISSN)

  • 0027-8424

Citation Source

  • Scopus