Polymorphism of human B-cell alloantigens: Evidence for three loci within the HLA system
The B-cell alloantigens of an HLA-DR3-homozygous, MB2-homozygous, MT2-positive lymphoblastoid cell line were studied by two-dimensional gel electrophoresis. Analysis of gel patterns suggested assignment of the HLA-DR3 determinant to the larger (35,000-dalton) subunit (α) of the B-cell alloantigen. MB2 was found to be either a determinant on the small (27,000 dalton) subunit (β) or a crossreactive determinant(s) on the HLA-DR3 α subunit and an additional α subunit, MT2 was found to be a determinant on Ia antigen-like molecules distinct from those carrying the MB and HLA-DR determinants. The results are consistent with the existence in the major histocompatibility complex of at least three loci encoding B-cell alloantigens.
Markert, ML; Cresswell, P
Volume / Issue
Start / End Page
International Standard Serial Number (ISSN)