Design of matched optical pulses for coherent Raman imaging


Journal Article

Coherent anti-Stokes Raman scattering (CARS) provides information on the Raman spectrum of a sample at greater signal strength than incoherent Raman scattering. The optical pulses are used which excites all vibrational modes of the molecules in the sample over a given bandwidth, but the pulse was conceived so that only a subset of modes would generate CARS signals that interfere constructively at a detector. The optical pulses reduces nonresonant background signal. The pulse design algorithm explicitly constructs an approximation to the matched filter of third-order nonlinear susceptibility in the time domain, subject to constraints of finite time support and realizability given an initial laser pulse spectrum. A heterodyne detection method could be used to further increase the instrument's sensitivity and a reference pulse is specifically shaped to have the form of the emitted CARS signal of a chemical species. The autocorrelation signal predicted from DNA is more than 10 times that of RNA so closely related biochemical species could be distinguished easily.

Full Text

Duke Authors

Cited Authors

  • Geddes, JB; Marks, DL; Boppart, SA

Published Date

  • January 1, 2009

Published In

Volume / Issue

  • 20 / 12

Start / End Page

  • 31 -

International Standard Serial Number (ISSN)

  • 1047-6938

Digital Object Identifier (DOI)

  • 10.1364/OPN.20.12.000031

Citation Source

  • Scopus