Group refractive index reconstruction with broadband interferometric confocal microscopy.


Journal Article

We propose a novel method of measuring the group refractive index of biological tissues at the micrometer scale. The technique utilizes a broadband confocal microscope embedded into a Mach-Zehnder interferometer, with which spectral interferograms are measured as the sample is translated through the focus of the beam. The method does not require phase unwrapping and is insensitive to vibrations in the sample and reference arms. High measurement stability is achieved because a single spectral interferogram contains all the information necessary to compute the optical path delay of the beam transmitted through the sample. Included are a physical framework defining the forward problem, linear solutions to the inverse problem, and simulated images of biologically relevant phantoms.

Full Text

Duke Authors

Cited Authors

  • Marks, DL; Schlachter, SC; Zysk, AM; Boppart, SA

Published Date

  • May 2008

Published In

Volume / Issue

  • 25 / 5

Start / End Page

  • 1156 - 1164

PubMed ID

  • 18451922

Pubmed Central ID

  • 18451922

Electronic International Standard Serial Number (EISSN)

  • 1520-8532

International Standard Serial Number (ISSN)

  • 1084-7529

Digital Object Identifier (DOI)

  • 10.1364/josaa.25.001156


  • eng