Nonlinear interferometric vibrational imaging of biological tissue


Journal Article

We demonstrate imaging with the technique of nonlinear interferometric vibrational imaging (NIVI). Experimental images using this instrumentation and method have been acquired from both phantom and biological tissues. In our system, coherent anti-Stokes Raman scattering (CARS) signals are detected by spectral interferometry, which is able to fully restore high resolution Raman spectrum on each focal spot of a sample covering multiple Raman bands using broadband pump and Stokes laser beams. Spectral-domain detection has been demonstrated and allows for a significant increase in image acquiring speed, in signal-to-noise, and in interferometric signal stability.

Full Text

Duke Authors

Cited Authors

  • Jiang, Z; Marks, DL; Geddes, JB; Boppart, SA

Published Date

  • April 21, 2008

Published In

Volume / Issue

  • 6860 /

International Standard Serial Number (ISSN)

  • 1605-7422

Digital Object Identifier (DOI)

  • 10.1117/12.763306

Citation Source

  • Scopus