Molecularly sensitive optical coherence tomography.


Journal Article

Molecular contrast in optical coherence tomography (OCT) is demonstrated by use of coherent anti-Stokes Raman scattering (CARS) for molecular sensitivity. Femtosecond laser pulses are focused into a sample by use of a low-numerical-aperture lens to generate CARS photons, and the backreflected CARS signal is interferometrically measured. With the chemical selectivity provided by CARS and the advanced imaging capabilities of OCT, this technique may be useful for molecular contrast imaging in biological tissues. CARS can be generated and interferometrically measured over at least 600 microm of the depth of field of a low-numerical-aperture objective.

Full Text

Duke Authors

Cited Authors

  • Bredfeldt, JS; Vinegoni, C; Marks, DL; Boppart, SA

Published Date

  • March 2005

Published In

Volume / Issue

  • 30 / 5

Start / End Page

  • 495 - 497

PubMed ID

  • 15789714

Pubmed Central ID

  • 15789714

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.30.000495


  • eng