Near-infrared dyes as contrast-enhancing agents for spectroscopic optical coherence tomography.


Journal Article

Optical coherence tomography (OCT) images of biological tissues often have low contrast. Spectroscopic optical coherence tomography (SOCT) methods have been developed to enhance contrast but remain limited because most tissues are not spectrally active in the frequency bands of laser sources commonly used in OCT. Near-infrared (NIR) dyes with absorption spectra features within the OCT source spectrum can be used for enhancing contrast in this situation. We introduce and demonstrate the use of NIR dyes as contrast agents for SOCT. Contrast-enhanced images are compared with fluorescence microscopy, demonstrating a link between SOCT and fluorescence imaging.

Full Text

Duke Authors

Cited Authors

  • Xu, C; Ye, J; Marks, DL; Boppart, SA

Published Date

  • July 1, 2004

Published In

Volume / Issue

  • 29 / 14

Start / End Page

  • 1647 - 1649

PubMed ID

  • 15309847

Pubmed Central ID

  • 15309847

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.29.001647


  • eng